The objective of this proposal is to support the applicant's development of an independent research program focusing on new treatment methods for renal vascular disease with magnetic resonance imaging (MRI) guidance. The candidate's immediate career goals are to gain animal research experience, learn and advance MRI techniques, and enhance clinical skills as an interventional radiologist. The candidate's long-term career objective is to become an active independent biomedical researcher.
He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality. To develop his research career, the candidate proposes learning: 1) fundamental MRI techniques related to blood vessel imaging and intervention, 2) swine experimental methods, and 3) methods for the responsible conduct of research. These skills will be acquired through a combination of coursework, MR technique workshops, weekly conferences, independent study, and interaction with sponsors/ advisory committee at Northwestern University Medical School. Sponsors include Drs. J. Paul Finn, Debiao Li, and Robert Vogelzang. The advisory committee also includes Drs. Dieter Enzmann and Francis Klocke. The broad, long-term objective of the research plan is to improve the prognosis of patients with renal vascular disease. In swine, the proposal aims to test the hypotheses that: 1) Intra-arterial gadolinium-enhanced magnetic resonance angiography (MRA) depicts renal arterial lumen caliber as accurately as x-ray angiography; 2) The technical success rate, complication rate, and procedure time for MRI-guided and x-ray guided percutaneous transluminal balloon angioplasty (PTA) of renal artery stenosis are similar; and 3) Successful MRI-guided PTA of renal artery stenosis improves kidney function as measured with MRI at the time of the procedure. If these hypotheses are shown to be correct, then the success and safety for MRI-guided PTA of renal artery stenosis will be confirmed. MRI will be useful to monitor immediate changes in kidney function at the time of renal artery PTA, an added value that cannot be performed using x-ray guidance. MRI guidance will also avoid the ionizing radiation exposure of x-rays and the potential kidney toxicity of iodinated contrast agents.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Clinical Investigator Award (CIA) (K08)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Rankin, Tracy L
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Northwestern University at Chicago
Schools of Medicine
United States
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Park, Jonathan K; Rhee, Thomas K; Cashen, Ty A et al. (2007) MR imaging assessment of changes in renal function with renal artery stent placement in swine. J Vasc Interv Radiol 18:1409-16
Rhee, Thomas K; Young, Joseph Y; Larson, Andrew C et al. (2007) Effect of transcatheter arterial embolization on levels of hypoxia-inducible factor-1alpha in rabbit VX2 liver tumors. J Vasc Interv Radiol 18:639-45
Park, Jonathan K; Rhee, Thomas K; Cashen, Ty A et al. (2007) Renal artery stenosis in swine: feasibility of MR assessment of renal function during percutaneous transluminal angioplasty. Radiology 244:144-50
Rhee, Thomas K; Park, Jonathan K; Cashen, Ty A et al. (2006) Comparison of intraarterial MR angiography at 3.0 T with X-ray digital subtraction angiography for detection of renal artery stenosis in swine. J Vasc Interv Radiol 17:1131-7
Omary, Reed A; Gehl, James A; Schirf, Brian E et al. (2006) MR imaging- versus conventional X-ray fluoroscopy-guided renal angioplasty in swine: prospective randomized comparison. Radiology 238:489-96
Green, Jordin D; Omary, Reed A; Schirf, Brian E et al. (2005) Three-dimensional contrast-enhanced steady-state free precession for improved catheter-directed coronary magnetic resonance angiography. J Magn Reson Imaging 22:415-9
Green, Jordin D; Omary, Reed A; Schirf, Brian E et al. (2005) Comparison of X-ray fluoroscopy and interventional magnetic resonance imaging for the assessment of coronary artery stenoses in swine. Magn Reson Med 54:1094-9
Rhee, Thomas K; Larson, Andrew C; Prasad, Pottumarthi V et al. (2005) Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits. J Vasc Interv Radiol 16:1523-8
Omary, Reed A; Schirf, Brian E; Green, Jordin D et al. (2005) Catheter-directed MR angiography and cross-sectional imaging for the assessment of renal artery stenosis. J Vasc Interv Radiol 16:255-60
Schirf, Brian E; Green, Jordin D; Sato, Kent et al. (2005) Determination of optimal gadolinium concentration using SSFP for catheter-directed contrast-enhanced coronary MR angiography. Acad Radiol 12:771-5

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