The goal of this research proposal is to test the hypothesis that human fetal oxygenation is a function of the placental surface area available for diffisional exchange, that maternal ventilation and erythropoiesis are functions of the metabolism of the fetal-placental unit; and that during constant adequate maternal nutrition, placental growth is function of maternal oxygenation. The testing of these 3 hypotheses will improve our understanding if two clinical entities - idiopathic intrauterine growth retardation and pregnancy induced hypertension. Both these clinical problems appear to be associated with decreased functional placental tissue resulting in inadequate fetal growth and failure of the maternal organism to make the compensatory increase in red cell mass, resulting in an inability to adequately increase cardiac output and therefore an inability to adequately perfuse the uteroplacental bed.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD000549-03
Application #
3081240
Study Section
Maternal and Child Health Research Committee (HDMC)
Project Start
1984-04-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bonds, D R; Cheek, T G; Crosby, L O et al. (1987) Term human fetal umbilical vein oxygen content, placental weight, and maternal blood pressure. J Perinatol 7:114-7
Bonds, D R; Crosby, L O; Cheek, T G et al. (1986) Estimation of human fetal-placental unit metabolic rate by application of the Bohr principle. J Dev Physiol 8:49-54