The immune system prevents reactivity against oneself;when this fails, autoimmune disease results. In pregnancy, the immune system also protects the fetus from the mother's immune system. When a mother develops preeclampsia, her immune system is overly active. Studies have shown that her cells react to her fetus's cells more than in normal pregnancies. This may represent """"""""rejection"""""""" of the fetus. Two types of immune cells are especially important in preventing reactions against oneself and the fetus. We propose to evaluate these cells;both number and function, in preeclampsia. If confirmed, problems with these cells may be targets for treatment. In addition, cells exchanged between a woman and her fetus, which is a normal part of pregnancy, contribute to the ability of the immune system to maintain tolerance during pregnancy and later in life. Additional studies aim to understand how this exchange of cells influences pregnancy outcomes.

Public Health Relevance

The proposed studies seek to understand why preeclampsia, a disease unique to pregnancy, develops. Preeclampsia is one of the leading causes of death and disease for women and their children globally. Understanding factors that lead to preeclampsia may lead to new strategies to treat or prevent its occurrence.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD067221-02
Application #
8475400
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Ilekis, John V
Project Start
2012-06-01
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$128,898
Indirect Cost
$9,548
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wallingford, Mary C; Gammill, Hilary S; Giachelli, Cecilia M (2016) Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells. Reprod Biol 16:13-26
Snyder, Matthew W; Simmons, LaVone E; Kitzman, Jacob O et al. (2015) Copy-number variation and false positive prenatal aneuploidy screening results. N Engl J Med 372:1639-45
Lannon, Sophia M R; Guthrie, Katherine A; Vanderhoeven, Jeroen P et al. (2015) Uterine rupture risk after periviable cesarean delivery. Obstet Gynecol 125:1095-100
Gammill, Hilary S; Milano, Filippo; Nelson, J Lee et al. (2015) Breastfeeding and Childhood Leukemia Incidence: Duplicate Data Inadvertently Included in the Meta-analysis and Consideration of Possible Confounders. JAMA Pediatr 169:1071
Snyder, Matthew W; Gammill, Hilary S; Shendure, Jay (2015) Copy-Number Variation and False Positive Results of Prenatal Screening. N Engl J Med 373:2585
Gammill, Hilary S; Stephenson, Mary D; Aydelotte, Tessa M et al. (2014) Microchimerism in women with recurrent miscarriage. Chimerism 5:103-5
Vanderhoeven, J P; Peterson, S E; Gannon, E E et al. (2014) Neonatal morbidity occurs despite pulmonary maturity prior to 39 weeks gestation. J Perinatol 34:322-5
Drury-Stewart, Danielle N; Lannert, Kerry W; Chung, Dominic W et al. (2014) Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. PLoS One 9:e112935
Gammill, Hilary S; Stephenson, Mary D; Aydelotte, Tessa M et al. (2014) Microchimerism in recurrent miscarriage. Cell Mol Immunol 11:589-94
Gammill, Hilary S (2014) Postpartum venous thromboembolic risk: one size may not fit all. Blood 124:2764-6

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