Motor vehicle crashes continue to be the leading cause of mortality and acquired disability in children. Traumatic brain and spinal cord injuries are typically considered the most disabling of these injuries. However, little is known about the specific patterns of injuries that lead to various degrees of functional disability in children and the biomechanical mechanisms for these crash-related disabling injuries. The broad long-term objective of this line of research is to advance the understanding of the nature and causes of functional disability after pediatric injury in sufficient detail to inorm secondary prevention (improved engineering and injury countermeasures) strategies as well as tertiary prevention (improved acute and rehabilitative care) strategies. As a first step in achieving this goal, the current proposal will focus on motor vehicle crashes as a prototypic mechanism of disabling injury in children.
The aims of the project are: 1) To identify the injuries for children 7-18 years old that are associated with moderate to severe functional disability upon discharge from rehabilitation centers, 2) To identify the crash characteristics, direction of impac, occupant contact points, and adequacy of restraint system performance that contribute to the moderately to severely disabling pattern of injuries, and to 3) To create a 3-dimensional dynamic computational model in order to quantify the crash biomechanics, simulate the occupant kinematics, and identify a countermeasure that could mitigate the biomechanical mechanism of injury.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Clinical Investigator Award (CIA) (K08)
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Study Section
Developmental Biology Subcommittee (CHHD)
Program Officer
Quatrano, Louis A
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Children's Hospital of Philadelphia
United States
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Myers, Rachel K; Eagan-Brown, Brenda L; Conway, Alexandra T et al. (2017) Examining a Statewide Educational Consulting Program for Pediatric Brain Injury. Clin Pediatr (Phila) :9922817732146
Zonfrillo, Mark R; Janigian, Nicholas G; Maron, Bradley A (2016) Death or Severe Injury at the Ball Game. Curr Sports Med Rep 15:132-3
Zonfrillo, Mark R; Macy, Michelle L; Cook, Lawrence J et al. (2016) Anticipated resource utilization for injury versus non-injury pediatric visits to emergency departments. Inj Epidemiol 3:12
Schoell, Samantha L; Weaver, Ashley A; Talton, Jennifer W et al. (2016) Functional outcomes of motor vehicle crash head injuries in pediatric and adult occupants. Traffic Inj Prev 17 Suppl 1:27-33
Henry, M Katherine; Wood, Joanne N; Metzger, Kristina B et al. (2016) Relationship between Insurance Type and Discharge Disposition From the Emergency Department of Young Children Diagnosed with Physical Abuse. J Pediatr 177:302-307.e1
Gaw, Christopher E; Zonfrillo, Mark R (2016) Emergency department visits for head trauma in the United States. BMC Emerg Med 16:5
Zonfrillo, Mark R; Zaniletti, Isabella; Hall, Matthew et al. (2016) Socioeconomic Status and Hospitalization Costs for Children with Brain and Spinal Cord Injury. J Pediatr 169:250-5
Henry, M Katherine; Zonfrillo, Mark R; French, Benjamin et al. (2016) Hospital Variation in Cervical Spine Imaging of Young Children With Traumatic Brain Injury. Acad Pediatr 16:684-91
Corwin, Daniel J; Wiebe, Douglas J; Zonfrillo, Mark R et al. (2015) Vestibular Deficits following Youth Concussion. J Pediatr 166:1221-5
Zonfrillo, Mark R; Ferguson, Rennie W; Walker, Lorrie (2015) Reasons for Child Passenger Nonrestraint in Motor Vehicles. Traffic Inj Prev 16 Suppl 2:S41-5

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