Abstract

The mechanisms of upper airway obstruction during NREM sleep are not well-understood. Increasing evidence suggests a relationship between breathing instability and upper airway obstruction in susceptible individuals. This protocol will examine the effect of several chemoreceptor perturbations, such as hypoxia, hypercapnia, and hypocapnia on the breathing instability and upper airway obstruction during NREM sleep. The study population will cover a wide spectrum of susceptibility to collapse from normals to snorers and patients with obstructive sleep apnea.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002588-02
Application #
3083014
Study Section
Special Emphasis Panel (SRC (JQ))
Project Start
1991-04-01
Project End
1996-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Badr, M S (1996) Effect of ventilatory drive on upper airway patency in humans during NREM sleep. Respir Physiol 103:1-10
Badr, M S; Kawak, A (1996) Post-hyperventilation hypopnea in humans during NREM sleep. Respir Physiol 103:137-45
Morrell, M J; Badr, M S; Harms, C A et al. (1995) The assessment of upper airway patency during apnea using cardiogenic oscillations in the airflow signal. Sleep 18:651-8
Badr, M S; Toiber, F; Skatrud, J B et al. (1995) Pharyngeal narrowing/occlusion during central sleep apnea. J Appl Physiol 78:1806-15
Badr, M S; Skatrud, J B; Dempsey, J A (1994) Effect of chemoreceptor stimulation and inhibition on total pulmonary resistance in humans during NREM sleep. J Appl Physiol 76:1682-92
Badr, M S; Grossman, J E; Weber, S A (1994) Treatment of refractory sleep apnea with supplemental carbon dioxide. Am J Respir Crit Care Med 150:561-4
Young, T; Palta, M; Dempsey, J et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230-5
Badr, M S; Skatrud, J B; Dempsey, J A (1992) Determinants of poststimulus potentiation in humans during NREM sleep. J Appl Physiol 73:1958-71