Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002926-03
Application #
2210797
Study Section
Special Emphasis Panel (ZHL1-CCT-M (M1))
Project Start
1994-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Mohle, R; Bautz, F; Rafii, S et al. (1999) Regulation of transendothelial migration of hematopoietic progenitor cells. Ann N Y Acad Sci 872:176-85;discussion 185-6
Mohle, R; Rafii, S; Moore, M A (1998) The role of endothelium in the regulation of hematopoietic stem cell migration. Stem Cells 16 Suppl 1:159-65
Mohle, R; Bautz, F; Rafii, S et al. (1998) The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 91:4523-30
Frey, B M; Hackett, N R; Bergelson, J M et al. (1998) High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors. Blood 91:2781-92
Frey, B M; Rafii, S; Teterson, M et al. (1998) Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis. J Immunol 160:691-9
Song, W; Kong, H L; Carpenter, H et al. (1997) Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J Exp Med 186:1247-56
Cannizzo, S J; Frey, B M; Raffi, S et al. (1997) Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA. Nat Biotechnol 15:570-3
Mohle, R; Moore, M A; Nachman, R L et al. (1997) Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line. Blood 89:72-80
Mohle, R; Green, D; Moore, M A et al. (1997) Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci U S A 94:663-8
Rafii, S; Mohle, R; Shapiro, F et al. (1997) Regulation of hematopoiesis by microvascular endothelium. Leuk Lymphoma 27:375-86

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