Substantial evidence indicates that susceptibility to chronic obstructive pulmonary disease (COPD) is influenced by genetic factors, yet identification of causative variants remains challenging. Most genetic studies of complex diseases such as COPD have focused on the role of common genetic variation. However, several complex disease studies have demonstrated the importance of rare variants;these variants have typically been of relatively strong effect. This proposal will test the hypothesis that both rare and common variants in candidate genes from monogenic human syndromes, genome-wide association studies, and/or mouse emphysema models contribute to COPD susceptibility. We will test this hypothesis in 400 subjects with severe emphysema from the National Emphysema Treatment Trial and a set of 400 smoking controls with normal lung function from the Normative Aging Study, using second-generation sequencing technology.
The specific aims are 1) variation discovery using a targeted, multiplexed approach on the Illumina Genome Analyzer;2) rare variant analysis, using a collapsing method to combine variants and increase power, and 3) common variant analysis, including replication in the Boston Early-Onset COPD Study.

Public Health Relevance

PUBLIC HEALTH RELEVANCE STATEMENT COPD is the fourth leading cause of death in the US. A comprehensive understanding of the genetic risk factors and pathobiology may lead to improvements in personalized diagnosis and treatment.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL097029-04
Application #
8464202
Study Section
Special Emphasis Panel (ZHL1-CSR-U (M1))
Program Officer
Tigno, Xenia
Project Start
2010-07-12
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
4
Fiscal Year
2013
Total Cost
$137,160
Indirect Cost
$10,160
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
McGeachie, Michael J; Yates, Katherine P; Zhou, Xiaobo et al. (2016) Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med 374:1842-52
Hobbs, Brian D; Parker, Margaret M; Chen, Han et al. (2016) Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 194:48-57
Szul, Tomasz; Castaldi, Peter; Cho, Michael H et al. (2016) Genetic regulation of expression of leukotriene A4 hydrolase. ERJ Open Res 2:
Putman, Rachel K; Hatabu, Hiroto; Araki, Tetsuro et al. (2016) Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA 315:672-81
Chang, Yale; Glass, Kimberly; Liu, Yang-Yu et al. (2016) COPD subtypes identified by network-based clustering of blood gene expression. Genomics 107:51-8
Qiao, Dandi; Lange, Christoph; Beaty, Terri H et al. (2016) Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 193:1353-63
Cho, Michael H; Castaldi, Peter J; Hersh, Craig P et al. (2015) A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med 192:559-69
Batmanghelich, Nematollah K; Saeedi, Ardavan; Cho, Michael et al. (2015) Generative Method to Discover Genetically Driven Image Biomarkers. Inf Process Med Imaging 24:30-42
Lutz, Sharon M; Cho, Michael H; Young, Kendra et al. (2015) A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet 16:138
Lee, Jin Hwa; Cho, Michael H; Hersh, Craig P et al. (2015) IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 52:365-76

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