This application is for Dr. Sanjay Basu, a physician-epidemiologist establishing himself in the field of statistical and modeling research on cardiovascular disease disparities. This award will allow Dr. Basu to: (1) develop a career focus in nutritional epidemiology and cardiovascular disease disparities;(2) learn how to implement """"""""systems science"""""""" mathematical modeling methods that simulate the impact of cardiovascular disease interventions;and (3) gain the necessary content expertise to address major unanswered questions in the epidemiology of cardiovascular disease disparities. To achieve these goals, Dr. Basu has assembled a mentoring team with expertise on nutrition and its relationship to cardiovascular disease risk;the epidemiology of cardiovascular disease disparities;and mathematical modeling. Dr. Basu's research proposal addresses disparities in the prevalence of hypertension between groups of different socioeconomic status (SES). The Institute of Medicine (IOM) has declared lower sodium consumption to be a national goal to reduce hypertension-related cardiovascular disease.2 Dr. Basu's research will test hypotheses about the relationship between social factors and sodium consumption among low-SES populations experiencing the highest prevalence of uncontrolled hypertension.3 In Aim 1, a regression tree analysis4 applied to the National Health and Nutrition Examination Survey will test the hypothesis that variations in sodium consumption within the population can be predicted using a few key sociodemographic variables.5 The analysis will identify what social factors can best explain heterogeneities in sodium intake within the US population.
In Aim 2, we will then test the hypothesis that an economic program incentivizing low-SES populations to increase the number of times per month they go grocery shopping can lead high-sodium consumers to substitute packaged products with fresh produce, thereby lowering their sodium consumption.6-8 To better assess causality, we will analyze a unique """"""""quasi-natural experiment"""""""" in Delaware, New Jersey and Pennsylvania in which a subset of households on food stamps were randomly allocated to receive benefits twice monthly instead of once monthly, which induced more frequent grocery shopping despite having the same overall monthly grocery budget as matched controls. The results of Aims 1 and 2 will be incorporated into a simulation model of hypertension in Aim 3. An agent-based model will be constructed to compare the impact of the program in Aim 2 to two other programs- front-of-package nutrition labeling9 and a vegetable voucher plan10-that attempt to influence consumers to reduce sodium consumption. The model will estimate the impact and cost-effectiveness of the interventions for reducing national hypertension disparities. This will form the basis of an R01 application to study novel sodium reduction strategies that target consumer food choice behaviors. This proposal addresses NHLBI strategic plan challenge 3.1, which encourages social science research incorporating """"""""systems science"""""""" modeling methods to investigate social factors and policy interventions to reduce health disparities.11

Public Health Relevance

Improving our understanding of the social factors and interventions that affect nutrition among low-SES populations is critical to effectively reducing disparities in cardiovascular disease. This study will specifically investigate what modifiable social factors and economic incentives may affect nutritional choice behaviors that influence sodium consumption. The research may help identify strategies to lower sodium intake among low- SES populations and reduce disparities in the prevalence of hypertension.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Clinical Investigator Award (CIA) (K08)
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Special Emphasis Panel (ZHL1)
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Wright, Jacqueline
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Stanford University
Internal Medicine/Medicine
Schools of Medicine
United States
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White, Justin S; Basu, Sanjay (2016) Does the benefits schedule of cash assistance programs affect the purchase of temptation goods? Evidence from Peru. J Health Econ 46:70-89
Basu, Sanjay; Yudkin, John S; Sussman, Jeremy B et al. (2016) Alternative Strategies to Achieve Cardiovascular Mortality Goals in China and India: A Microsimulation of Target- Versus Risk-Based Blood Pressure Treatment. Circulation 133:840-8
Basu, Sanjay; Kiernan, Michaela (2016) A Simulation Modeling Framework to Optimize Programs Using Financial Incentives to Motivate Health Behavior Change. Med Decis Making 36:48-58
White, Justin S; Hamad, Rita; Li, Xinjun et al. (2016) Long-term effects of neighbourhood deprivation on diabetes risk: quasi-experimental evidence from a refugee dispersal policy in Sweden. Lancet Diabetes Endocrinol 4:517-24
Basu, Sanjay; Wimer, Christopher; Seligman, Hilary (2016) Moderation of the Relation of County-Level Cost of Living to Nutrition by the Supplemental Nutrition Assistance Program. Am J Public Health 106:2064-2070
Choi, Sung Eun; Brandeau, Margaret L; Basu, Sanjay (2016) Expansion of the National Salt Reduction Initiative: A Mathematical Model of Benefits and Risks of Population-Level Sodium Reduction. Med Decis Making 36:72-85
Basu, Sanjay; Bendavid, Eran; Sood, Neeraj (2015) Health and Economic Implications of National Treatment Coverage for Cardiovascular Disease in India: Cost-Effectiveness Analysis. Circ Cardiovasc Qual Outcomes 8:541-51
Basu, Sanjay; Siddiqi, Arjumand (2015) Basu and Siddiqi Respond to ""Context, Behaviors, and Hypertension Inequalities"". Am J Epidemiol 182:358
Basu, Sanjay; Hong, Anthony; Siddiqi, Arjumand (2015) Using Decomposition Analysis to Identify Modifiable Racial Disparities in the Distribution of Blood Pressure in the United States. Am J Epidemiol 182:345-53