: Out-of-pocket costs comprise approximately one-sixth of health care expenditures and nearly one-half of expenditures on prescription medicines. These costs pose a burden on many patients and are associated with non-adherence and other barriers to quality care. Dr. Alexander's previous work suggests that patient physician communication about out-of-pocket prescription costs is an important yet neglected aspect of current clinical practice. Such findings may be especially relevant to elderly patients who are more likely to be on multiple medications and have fixed incomes. In this proposed randomized trial, Dr. Alexander will develop, implement, and evaluate the effectiveness of an intervention designed to assist patients and physicians in safely reducing patients' out-of-pocket prescription costs. One hundred and eighty patients treated by 45 general internists and geriatricians will be recruited for the study from 8 physician practices. The intervention includes both patient- and physician-targeted strategies designed to overcome previously identified barriers to reducing patients' out-of-pocket costs. Primary outcomes of the study will be compared between baseline and six to eight weeks following patients' index office visit and include the impact of the ? intervention on out-of-pocket costs, medication appropriateness, health status, and burden from out-of pocket costs. Secondary outcomes will examine the effect of the interventions on rates of patient-physician discussions about costs, how changes in out-of-pocket costs are achieved (e.g. switching from brand name to generic equivalent), and barriers that may prevent enhanced intervention effectiveness (e.g. patient discomfort initiating discussions about prescription costs). The recently passed Medicare Modernization Act makes this research especially relevant because it leaves substantial gaps in coverage for beneficiaries of average means who incur high drug expenses. As a former Robert Wood Johnson Clinical Scholar with an established track record examining patient-physician communication about out-of-pocket costs, Dr. Alexander is in an ideal candidate to explore this important interface between bioethics, health policy, and clinical medicine. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HS015699-02
Application #
7176897
Study Section
HSR Health Care Research Training SS (HCRT)
Program Officer
Anderson, Kay
Project Start
2006-02-08
Project End
2011-01-31
Budget Start
2007-02-01
Budget End
2008-01-31
Support Year
2
Fiscal Year
2007
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Chien, Alyna T; Chin, Marshall H; Alexander, G Caleb et al. (2014) Physician financial incentives and care for the underserved in the United States. Am J Manag Care 20:121-9
Schwarze, Margaret L; Redmann, Andrew J; Alexander, G Caleb et al. (2013) Surgeons expect patients to buy-in to postoperative life support preoperatively: results of a national survey. Crit Care Med 41:1-8
Paul Olson, Terrah J; Brasel, Karen J; Redmann, Andrew J et al. (2013) Surgeon-reported conflict with intensivists about postoperative goals of care. JAMA Surg 148:29-35
Higashi, Ashley; Zhu, Shu; Stafford, Randall S et al. (2011) National trends in ambulatory asthma treatment, 1997-2009. J Gen Intern Med 26:1465-70
Alexander, G Caleb; O'Connor, Alec B; Stafford, Randall S (2011) Enhancing prescription drug innovation and adoption. Ann Intern Med 154:833-7, W-301
Alexander, G C; Gallagher, S A; Mascola, A et al. (2011) Increasing off-label use of antipsychotic medications in the United States, 1995-2008. Pharmacoepidemiol Drug Saf 20:177-84
Liu, Frank Xiaoqing; Alexander, G Caleb; Crawford, Stephanie Y et al. (2011) The impact of Medicare Part D on out-of-pocket costs for prescription drugs, medication utilization, health resource utilization, and preference-based health utility. Health Serv Res 46:1104-23
Qato, Dima M; Lindau, Stacy Tessler; Conti, Rena M et al. (2010) Racial and ethnic disparities in cardiovascular medication use among older adults in the United States. Pharmacoepidemiol Drug Saf 19:834-42
Lale, Allison; Moloney, Rachael; Alexander, G Caleb (2010) Academic medical centers and underserved communities: modern complexities of an enduring relationship. J Natl Med Assoc 102:605-13
Torke, Alexia M; Moloney, Rachael; Siegler, Mark et al. (2010) Physicians' views on the importance of patient preferences in surrogate decision-making. J Am Geriatr Soc 58:533-8

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