Studies of Attention-Deficit/Hyperactivity Disorder (ADHD) within birth-records-based Missouri population samples suggest that a severe combined subtype of ADHD defined by population-based criteria is a distinct form of ADHD deserving of further characterization. Specifically, this population-defined form of ADHD appears to be a genetically distinct disorder, with a characteristic developmental profile that includes elevated levels of autistic symptoms and motor problems. The current project aims to replicate and expand upon the above findings using available datasets plus additional assessments that will aid in characterizing the neurodevelopmental phenotype of children with severe combined type ADHD. Also, the project will use family history data to determine whether the combination of severe combined type ADHD plus motor and/or social deficits is an indicator of family genetic risk for psychiatric illnesses other than ADHD itself. Major hypotheses of this project include: 1) Severe combined type ADHD is associated with high rates of autistic traits and motor problems as measured by standard assessment tools, 2) Within individuals with severe combined type ADHD, the degree of motor impairment is associated with the degree of autistic traits. 3) Specific patterns of motor problems, autistic traits and ADHD symptoms will cluster within individuals and within families. 4) Individuals with severe combined ADHD plus motor and/or social deficits will have a stronger family history of psychiatric illness than individuals with severe combined ADHD alone. Refinement of naturally-occurring ADHD phenotypes involving autistic traits and/or motor problems may facilitate future genetic studies, longitudinal outcome studies, and clinical treatment trials. This project is relevant to public health because improved diagnostic classification of childhood and adolescent disorders such as ADHD and autism spectrum disorders may eventually lead to better screening, prevention, and treatment of such disorders within the population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH080287-05
Application #
8277455
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Gilotty, Lisa
Project Start
2008-09-05
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$160,519
Indirect Cost
$11,890
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
De Alwis, Duneesha; Lynskey, Michael T; Reiersen, Angela M et al. (2014) Attention-deficit/hyperactivity disorder subtypes and substance use and use disorders in NESARC. Addict Behav 39:1278-85
De Alwis, Duneesha; Agrawal, Arpana; Reiersen, Angela M et al. (2014) ADHD symptoms, autistic traits, and substance use and misuse in adult Australian twins. J Stud Alcohol Drugs 75:211-21
Reiersen, Angela M; Todorov, Alexandre A (2013) Exploration of ADHD Subtype Definitions and Co-Occurring Psychopathology in a Missouri Population-Based Large Sibship Sample. Scand J Child Adolesc Psychiatr Psychol 1:3-13
Reiersen, Angela M; Todorov, Alexandre A (2011) Association between DRD4 genotype and Autistic Symptoms in DSM-IV ADHD. J Can Acad Child Adolesc Psychiatry 20:15-21
Reiersen, Angela M; Handen, Benjamin (2011) Commentary on 'Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)' Evid Based Child Health 6:1082-1085
Ramtekkar, Ujjwal P; Reiersen, Angela M; Todorov, Alexandre A et al. (2010) Sex and age differences in attention-deficit/hyperactivity disorder symptoms and diagnoses: implications for DSM-V and ICD-11. J Am Acad Child Adolesc Psychiatry 49:217-28.e1-3