This mentored career development award will advance the career of Dr. Nandakumar Narayanan towards becoming an independent physician-scientist focused on the mechanism of cognitive dysfunction in Parkinson's disease. Currently, there are no treatments for cognitive dysfunction in Parkinson's disease and the mechanism is unclear. Dr. Narayanan proposes experiments that leverage state-of-the art techniques for selectively recording, disrupting, and stimulating neurons in freely-moving, behaving animals. The proposed research will interrogate the mechanism of cognitive dysfunction in Parkinson's disease. This proposal could inspire new therapeutic strategies for cognitive symptoms of PD based on existing gene therapy, functional neurosurgery and brain stimulation approaches. Dr. Narayanan has a strong neuroscience background with a PhD in neuroscience, and has identified an outstanding mentorship team. His primary mentor will be Dr. Ralph DiLeone, an innovative molecular biologist who will teach him novel tools to unravel neural circuits. In parallel, he will extend his neurological training to master all aspects of carng for patients with Parkinson's disease and with deep-brain stimulation. His training will occur in a vibrant neuroscience community with robust departmental support. From these efforts, he will learn a unique skill set to explore the mechanism of cognitive dysfunction in Parkinson's disease. This mentored career development award will position Dr. Narayanan to translate insights from his basic research to the clinical arena to help patients with Parkinson's disease.

Public Health Relevance

Cognitive symptoms in Parkinson's disease cause morbidity and mortality, and have no effective treatments. This proposal explores the mechanism of cognitive dysfunction in animal model with the hope of generating new treatments for cognitive dysfunction in Parkinson's disease.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Clinical Investigator Award (CIA) (K08)
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NST-2 Subcommittee (NST)
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Sieber, Beth-Anne
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Yale University
Schools of Medicine
New Haven
United States
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van den Heuvel, José K; Furman, Kara; Gumbs, Myrtille C R et al. (2015) Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biol Psychiatry 77:633-41
Rodnitzky, Robert L; Narayanan, Nandakumar S (2014) Amantadine's role in the treatment of levodopa-induced dyskinesia. Neurology 82:288-9
Lamichhane, Dronacharya; Narayanan, N S; Gonzalez-Alegre, Pedro (2014) Two cases of pregnancy in Parkinson's disease. Parkinsonism Relat Disord 20:239-40
Parker, Krystal L; Narayanan, Nandakumar S; Andreasen, Nancy C (2014) The therapeutic potential of the cerebellum in schizophrenia. Front Syst Neurosci 8:163
Parker, Krystal L; Lamichhane, Dronacharya; Caetano, Marcelo S et al. (2013) Executive dysfunction in Parkinson's disease and timing deficits. Front Integr Neurosci 7:75
Parker, K L; Alberico, S L; Miller, A D et al. (2013) Prefrontal D1 dopamine signaling is necessary for temporal expectation during reaction time performance. Neuroscience 255:246-54
Fattahi, Pooia; Sheriff, Faheem; Narayanan, Nandakumar S et al. (2013) Thrombolysis for acute stroke in patients with vasculitis: case report and literature discussion. Clin Neurol Neurosurg 115:351-3
Narayanan, Nandakumar S; Cavanagh, James F; Frank, Michael J et al. (2013) Common medial frontal mechanisms of adaptive control in humans and rodents. Nat Neurosci 16:1888-95
Narayanan, Nandakumar S; Rodnitzky, Robert L; Uc, Ergun Y (2013) Prefrontal dopamine signaling and cognitive symptoms of Parkinson's disease. Rev Neurosci 24:267-78