The major goal of the research plan to be pursued is to determine the relationship of certain lymphocyte cell surface molecules to immunodeficiency disease states such as AIDS. There are three main aims: a) to evaluate the genetic polymorphism of the human CD4 and CD8 molecules in a broad based population (b) to determine if polymorphisms in either CD4 or CD8 are related to either susceptibility to HIV infection progression of disease (c) to determine if there is a correlation between the genetic structure of CD4 and CD8 and primary immunodeficiency diseases with T cell abnormalities. Methods to be used include population studies, DNA sequencing, polymerase chain reaction, molecular genetic cloning techniques, family studies, and patient evaluations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Physician Scientist Award (K11)
Project #
5K11AI000944-04
Application #
3085315
Study Section
Special Emphasis Panel (SRC (22))
Project Start
1990-05-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
110521739
City
Menands
State
NY
Country
United States
Zip Code
12204
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Wade, N; Flaherty, L (1993) DNA sequence analysis and polymorphism of the mouse CD4 gene. Immunogenetics 38:384