Although knowledge of cancer biology in the laboratory has increased exponentially in recent years, progress in cancer treatment in the clinic has been more gradual. To accelerate progress in the clinic, a larger number of outstanding clinician-investigators is needed to perform patient-oriented, therapeutic translational research. The M. D. Anderson (MDACC) K12 Paul Calabresi Program in Clinical Oncology has taken advantage of an extraordinary environment for clinical and translational research to begin to fill this need. MDACC brings together 1,469 faculty and 29,500 new patients each year with a well-developed infrastructure for clinical and laboratory research and novel ideas that are supported by 254 NCI grants. For 6 decades, MDACC investigators have made important contributions to clinical cancer research. Since the inception of the MDACC K12 Program in 2000, 9 junior-faculty investigators have been trained in patient- based translational research with the program's support. Currently four faculty investigators and two fellows are being trained in this program. All nine of our graduates have become highly productive clinician- scientists, who have published 388 peer-reviewed papers, competed successfully for $10.9 M in grants and contracts and have headed 89 therapeutic protocols. The four faculty and two fellow trainees supported by this award will conduct hypothesis driven clinical trials, participate in a cancer-oriented K30 curriculum and can earn an M.S./Ph.D. in Patient-Based Biological Research. To maximize use of MDACC's extensive resources for clinical, translational and basic research, this combined K12 program will include fellows and junior faculty not only from MDACC but also from the Baylor College of Medicine. This program emphasizes individualized training plans that include didactic classes, clinical trials, laboratory research projects, publication of results, individualized training experiences, and long-range planning. Each Calabresi scholar is guided by a clinical mentor and a translational mentor as well as by the PI and the program's Advisory Committee, composed of experts in clinical, laboratory, and translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12CA088084-15
Application #
8731625
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (J))
Program Officer
Damico, Mark W
Project Start
2000-09-13
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
$251,041
Indirect Cost
$47,575
Name
University of Texas MD Anderson Cancer Center
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Wu, Xifeng; Ye, Yuanqing; Barcenas, Carlos H et al. (2017) Personalized Prognostic Prediction Models for Breast Cancer Recurrence and Survival Incorporating Multidimensional Data. J Natl Cancer Inst 109:
Cardenas, Carlos E; Mohamed, Abdallah S R; Tao, Randa et al. (2017) Prospective Qualitative and Quantitative Analysis of Real-Time Peer Review Quality Assurance Rounds Incorporating Direct Physical Examination for Head and Neck Cancer Radiation Therapy. Int J Radiat Oncol Biol Phys 98:532-540
Rosenthal, David I; Mohamed, Abdallah S R; Garden, Adam S et al. (2017) Final Report of a Prospective Randomized Trial to Evaluate the Dose-Response Relationship for Postoperative Radiation Therapy and Pathologic Risk Groups in Patients With Head and Neck Cancer. Int J Radiat Oncol Biol Phys 98:1002-1011
MD Anderson Head and Neck Cancer Symptom Working Group (2017) Dose-volume correlates of mandibular osteoradionecrosis in Oropharynx cancer patients receiving intensity-modulated radiotherapy: Results from a case-matched comparison. Radiother Oncol 124:232-239
Hutcheson, Katherine A; Barrow, Martha P; Barringer, Denise A et al. (2017) Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation. Cancer 123:62-70
Holman, Laura L; Pal, Navdeep; Iglesias, David A et al. (2017) Factors prognostic of survival in advanced-stage uterine serous carcinoma. Gynecol Oncol 146:27-33
Ikoma, Naruhiko; Torres, Keila E; Lin, Heather Y et al. (2017) Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery. J Surg Oncol 116:313-319
Ikoma, Naruhiko; Araujo, Dejka; Roland, Christina L (2017) The Hereditary Paraganglioma-Pheochromocytoma Syndrome: No Time to Waste-Reply. JAMA Oncol 3:1740
MICCAI/M.D. Anderson Cancer Center Head and Neck Quantitative Imaging Working Group (2017) Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges. Sci Data 4:170077
Zhu, Lijun; Sturgis, Erich M; Zhang, Hua et al. (2017) Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx. Int J Cancer 141:1355-1364

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