The University of Chicago has long recognized the importance of physician scientists capable of utilizing laboratory discoveries to evolve novel therapeutic approaches and using clinical observations to inform and shape basic investigations. The University has an enviable record of training the next generation of academic oncologists. However, the training of academic leaders with critical expertise in clinical and translational research has become increasingly difficult, mandating the creation of a tightly structured and mentored training environment. Leveraging our current training programs (CTSA, K30 award, non-Roadmap K12 awards, traditional T32 training, K08/K23 mentoring programs), we will create an interdisciplinary program in patient-oriented research to train clinicians and basic scientists to lead interdisciplinary teams that will transform the practice of oncology. The Paul Calabresi K12 Scholars Program is our highly mentored, didactic coursework-intensive program, and """"""""hands on"""""""" clinical research training which results in a Master of Science in Health Studies. These scholars are clinical oncologists finishing fellowship training, clinical faculty who wish to change career emphasis, or a scientist with a health-related PhD who wishes to work in the clinical sphere. The strength of our clinical programs coupled with our research intensity and our focus on genetics/genomics research makes the University of Chicago an ideal institution for the preparation of a clinical oncology workforce for the era of personalized medicine. Through this training program will emerge bonafide translational researchers and clinical oncologists who will possess the knowledge and capacity to conduct bench to bedside research and translate their findings back to patients and the population. It is our expectation that individuals completing this program will have obtained the broad research training and comprehensive experience necessary to perform high quality and high impact hypothesis-based clinical and translational research and to make fundamental contributions towards the goal of personalized cancer treatment. An explicit goal of this Paul Calabresi Scholars program, as with all training programs in our institution, is that its training opportunities and benefits will extend far beyond the relatively few scholars whose stipends it will provide. We are confident that the program will reach into the larger oncology trainee community at our University and in Chicago and to young scientists pursuing careers in cancer research all over the globe. Thus, the benefit that accrues from the program's implementation will be substantial.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
White, Michael G; James, Benjamin C; Nocon, Cheryl et al. (2016) One-hour PTH after thyroidectomy predicts symptomatic hypocalcemia. J Surg Res 201:473-9
Morrison, Gladys; Lenkala, Divya; LaCroix, Bonnie et al. (2016) Utility of patient-derived lymphoblastoid cell lines as an ex vivo capecitabine sensitivity prediction model for breast cancer patients. Oncotarget 7:38359-38366
Kanteti, Rajani; Dhanasingh, Immanuel; El-Hashani, Essam et al. (2016) C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther 17:91-103
Nielsen, Sarah M; White, Michael G; Hong, Susan et al. (2016) The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis. Cancer Epidemiol Biomarkers Prev 25:231-8
O'Donnell, Peter H; Alanee, Shaheen; Stratton, Kelly L et al. (2016) Clinical Evaluation of Cisplatin Sensitivity of Germline Polymorphisms in Neoadjuvant Chemotherapy for Urothelial Cancer. Clin Genitourin Cancer 14:511-517
Shah, Shalin; Ward, James E; Bao, Riyue et al. (2016) Clinical Response of a Patient to Anti-PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors. Cancer Immunol Res 4:903-909
Ezewuiro, Obiageli; Grushko, Tatyana A; Kocherginsky, Masha et al. (2016) Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy. PLoS One 11:e0147145
Vasanthakumar, Aparna; Arnovitz, Stephen; Marquez, Rafael et al. (2016) Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice. Blood 127:310-3
van Besien, Koen; Hari, Parameswaran; Zhang, Mei-Jie et al. (2016) Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival. Haematologica 101:634-43
Catenacci, Daniel V T; Liao, Wei-Li; Zhao, Lei et al. (2016) Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH. Gastric Cancer 19:1066-79

Showing the most recent 10 out of 76 publications