Columbia University is uniquely positioned to develop scientists and/or clinicians towards independent research careers in temporomandibular joint disorders and pain (TMJDP). Through strategic recruitment in the past ~5 years, Columbia University College of Dental Medicine (CDM) now has a critical mass of NIH funded, primary and secondary faculty members whose research is directly in TMJDP. In parallel, multiple clusters of key recruitments in medical and engineering schools have yielded cadres of leading scientists in molecular genetics, biomaterials, chemical engineering and bioengineering whose expertise, when integrated with TMJDP, generates powerful and novel approaches. Collectively, our faculty mentors have over 28 NIH R01s that offer both the breadth and depth to trainees that will be recruited on this grant. Prior to this FOA, the CDM has established a track record of career development of multiple junior faculty members, with one example of a dentist/scientist whose work in novel TMJ stem/progenitor cells has received NIDCR K99/R00 funding, in addition to recognition as 1st place Hatton Awardees separately at 2012 AADR and IADR Conferences. This TMJDP training program has built key partnerships and leveraged tremendous resources that are currently available at Columbia. Interdisciplinary research is a particular strength at Columbia, with existing collaborations among dentistry, medicine, engineering, biological science and public health. The long-standing TMJ/Orofacial Pain Clinic (est. 1949) treats a broad range of patients not only in New York City, but also surrounding areas of New York, New Jersey, Connecticut and Northern Philadelphia, offering a fertile platform for translational and clinical research. Columbia University in the City of New York attracts abundant candidates with diverse academic, clinical, social and ethnic background, including underrepresented minorities, by offering them a broad range of learning opportunities. The overall objective of this K12 proposal is to prepare and develop scientists and/or clinicians into independent research investigators in TMJDP. We will set up a sustainable pipeline of Recruitment, Mentorship and Career Transition (RMCT). We will take a trainee-centered approach, very much along the Columbia tradition to focus on each student by maximizing his/her own learning experience. In response to this FOA, our Internal Steering Committee has performed a SWOP analysis (Strengths, Weaknesses, Opportunities and Threats) and consulted members of our Internal and External Advisory Panels. Accordingly, we have set the following 3 training tracks: Genetics/Physiology, Bioengineering/Regeneration and Imaging/Biomechanics. Our long-term goal, above and beyond this 5-year grant, is to continue with a successful and sustainable program to develop independent research investigators in TMJDP and other areas of dental and craniofacial research.

Public Health Relevance

Patients with 'TMJ' or jaw joint problems suffer from pain and inability to intake foods. This proposal is designed to develop independent research career for highly selected candidates, including underrepresented minorities, who devote their research to TMJ and pain research. .

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
4K12DE023583-04
Application #
9112988
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Robinson, J L; Gupta, V; Soria, P et al. (2017) Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice. Orthod Craniofac Res 20 Suppl 1:167-171
Robinson, J L; Cass, K; Aronson, R et al. (2017) Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading. Osteoarthritis Cartilage 25:533-543
Lee, Nancy; Robinson, Jennifer; Lu, Helen (2016) Biomimetic strategies for engineering composite tissues. Curr Opin Biotechnol 40:64-74
Jiang, Nan; Guo, Weihua; Chen, Mo et al. (2016) Periodontal Ligament and Alveolar Bone in Health and Adaptation: Tooth Movement. Front Oral Biol 18:1-8
Zhou, Chen; Yang, Guodong; Chen, Mo et al. (2015) Lhx6 and Lhx8: cell fate regulators and beyond. FASEB J 29:4083-91
Zheng, Y; Chen, M; He, L et al. (2015) Mesenchymal dental pulp cells attenuate dentin resorption in homeostasis. J Dent Res 94:821-7
Zhou, Chen; Yang, Guodong; Chen, Mo et al. (2015) Lhx8 mediated Wnt and TGF? pathways in tooth development and regeneration. Biomaterials 63:35-46
Sun, Guoming; Mao, Jeremy J (2012) Engineering dextran-based scaffolds for drug delivery and tissue repair. Nanomedicine (Lond) 7:1771-84