This application seeks support for a Multidisciplinary K12 Urologic Research (KURe) Career Development Program at the Scott Department of Urology at Baylor College of Medicine. The research emphasis of this program is in the areas of Lower Urinary Tract Symptoms, male reproductive biology and infertility, as well as pediatric urology/genitourinary development. The training faculty includes 10 Ph.D/M.D., Ph.D. mentors and 5 M.D. clinical advisors. Dr. Lamb will serve as Program Director and Dr. Boone as Co-Director of the KURe. The major research areas in the program include: cell biology, steroid hormone receptors and growth factor signaling, male reproductive biology, genetics, aging, pediatric urology/developmental biology and gene disruption. The trainees will be Ph.D. fellows, M.D. fellows/Junior Faculty. Our program attracts highly qualified trainees who seek an intensive and substantial research training in men's health research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high national ranking for NIH funding of a Urology department, a structured mentoring and pilot project program and required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Our long-term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in urologic research.

Public Health Relevance

This application focuses on a plan to train young Urologists and Ph.D. fellows in basic and translation research in areas of Urology relating to problems of lower urinary tract symptoms (benign prostatic hyperplasia, erectile dysfunction and bladder storage and voiding problems), birth defects and the controls of basic testis and genital tract function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK083014-03
Application #
7932964
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (O1))
Program Officer
Rankin, Tracy L
Project Start
2008-09-30
Project End
2013-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
3
Fiscal Year
2010
Total Cost
$995,255
Indirect Cost
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Gabrielsen, J Scott; Lamb, Dolores J; Lipshultz, Larry I (2018) Iron and a Man's Reproductive Health: the Good, the Bad, and the Ugly. Curr Urol Rep 19:60
White, Jeffrey T; Sheth, Kunj R; Bilgutay, Aylin E et al. (2018) Vesicoamniotic Shunting Improves Outcomes in a Subset of Prune Belly Syndrome Patients at a Single Tertiary Center. Front Pediatr 6:180
Thirumavalavan, Nannan; Cordon, Billy H; Gross, Martin S et al. (2018) Rear Tip Extenders and Penile Prosthesis Rigidity: A Laboratory Study of Coloplast Prostheses. J Sex Med 15:1030-1033
Thirumavalavan, Nannan; Scovell, Jason M; Link, Richard E et al. (2018) Does Solid Organ Transplantation Affect Male Reproduction? Eur Urol Focus 4:307-310
High, Rachel; Kavanagh, Alex; Khavari, Rose et al. (2018) Procedure Choice in Primary Versus Recurrent Prolapse: A Study of Fellowship-Trained Surgeons. Female Pelvic Med Reconstr Surg 24:277-280
Butaney, Mohit; Thirumavalavan, Nannan; Hockenberry, Mark S et al. (2018) Variability in penile duplex ultrasound international practice patterns, technique, and interpretation: an anonymous survey of ISSM members. Int J Impot Res 30:237-242
Thirumavalavan, Nannan; Hoover, Christopher R V; Gross, Martin S (2018) Surgeons Corner: Cavernoscopy for Rear Tip Extender Removal. J Sex Med 15:1195-1197
Thirumavalavan, Nannan; Scovell, Jason M; Balasubramanian, Adithya et al. (2018) The Impact of Microsurgical Repair of Subclinical and Clinical Varicoceles on Total Motile Sperm Count: Is There a Difference? Urology 120:109-113
Alge, Joseph L; Wenderfer, Scott E; Hicks, John et al. (2017) Hemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report. BMC Nephrol 18:243
Kaviani, Aaron; Khavari, Rose (2017) Disease-Specific Outcomes of Botulinum Toxin Injections for Neurogenic Detrusor Overactivity. Urol Clin North Am 44:463-474

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