This application seeks support for a Multidisciplinary K12 Urologic Research (KURe) Career Development Program at the Scott Department of Urology at Baylor College of Medicine. The research emphasis of this program is in the areas of Lower Urinary Tract Symptoms, male reproductive biology and infertility, as well as pediatric urology/genitourinary development. The training faculty includes 10 Ph.D/M.D., Ph.D. mentors and 5 M.D. clinical advisors. Dr. Lamb will serve as Program Director and Dr. Boone as Co-Director of the KURe. The major research areas in the program include: cell biology, steroid hormone receptors and growth factor signaling, male reproductive biology, genetics, aging, pediatric urology/developmental biology and gene disruption. The trainees will be Ph.D. fellows, M.D. fellows/Junior Faculty. Our program attracts highly qualified trainees who seek an intensive and substantial research training in men's health research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high national ranking for NIH funding of a Urology department, a structured mentoring and pilot project program and required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Our long-term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in urologic research.

Public Health Relevance

This application focuses on a plan to train young Urologists and Ph.D. fellows in basic and translation research in areas of Urology relating to problems of lower urinary tract symptoms (benign prostatic hyperplasia, erectile dysfunction and bladder storage and voiding problems), birth defects and the controls of basic testis and genital tract function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK083014-05
Application #
8323460
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (O1))
Program Officer
Rankin, Tracy L
Project Start
2008-09-30
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$995,255
Indirect Cost
$73,723
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Jorgez, Carolina J; Rosenfeld, Jill A; Wilken, Nathan R et al. (2014) Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1. PLoS One 9:e107028
Szafran, Adam T; Mancini, Michael A (2014) The myImageAnalysis project: a web-based application for high-content screening. Assay Drug Dev Technol 12:87-99
Tannour-Louet, Mounia; Han, Shuo; Louet, Jean-Francois et al. (2014) Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med 20:715-24
Kovac, Jason R; Pan, Michael M; Lipshultz, Larry I et al. (2014) Current state of practice regarding testosterone supplementation therapy in men with prostate cancer. Steroids 89:27-32
Hwang, Kathleen; Lamb, Dolores J (2013) The sperm penetration assay for the assessment of fertilization capacity. Methods Mol Biol 927:103-11
Bolt, Michael J; Stossi, Fabio; Newberg, Justin Y et al. (2013) Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses. Nucleic Acids Res 41:4036-48
Hosain, G M Monawar; Latini, David M; Kauth, Michael R et al. (2013) Racial differences in sexual dysfunction among postdeployed Iraq and Afghanistan veterans. Am J Mens Health 7:374-81
Hosain, G M Monawar; Latini, David M; Kauth, Michael et al. (2013) Sexual dysfunction among male veterans returning from Iraq and Afghanistan: prevalence and correlates. J Sex Med 10:516-23
Shy, Michael; Fletcher, Sophie G (2013) Objective Evaluation of Overactive Bladder: Which Surveys Should I Use? Curr Bladder Dysfunct Rep 8:45-50
Slattery, Scott D; Newberg, Justin Y; Szafran, Adam T et al. (2012) A framework for image-based classification of mitotic cells in asynchronous populations. Assay Drug Dev Technol 10:161-78

Showing the most recent 10 out of 17 publications