This application seeks support for our competing renewal application for the Multidisciplinary K12 Urologic Research (KURe) Career Development Program to the Scott Department of Urology and the Center for Reproductive Medicine at Baylor College of Medicine. The research emphasis of this program is in the areas pediatric urology/genitourinary development, steroid hormone action, stem cells genetics and lower urinary tract symptoms (LUTS). The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Administrative Director of the KURe career development program. Dr. Boone will serve as co-Director. Drs. Lipshultz, Cunningham, Gonzales, Khera, Roth, Janzen will ensure the M.D. trainees are optimally trained in the urologic subspecialty areas of men's health and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive tract biology, genetics, cell cycle control, stem cells, gene therapy and LUTS. The trainees will be M.D. and Ph.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in urology research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology/Cell Biology/Genetics/Pathology departments, a structured mentoring program with required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Most importantly, we have a strong track record of training successful physician scientists. Our long- term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research.

Public Health Relevance

This KURe K12 application will train new investigators to become clinical and basic researchers in urologic health issues. This program will offer training in both basic and clinical research to investigators to improve urologic health.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-R (M3))
Program Officer
Rankin, Tracy L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Schools of Medicine
United States
Zip Code
Szafran, Adam T; Stossi, Fabio; Mancini, Maureen G et al. (2017) Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis. PLoS One 12:e0180141
Kaviani, Aaron; Khavari, Rose (2017) Disease-Specific Outcomes of Botulinum Toxin Injections for Neurogenic Detrusor Overactivity. Urol Clin North Am 44:463-474
Elizondo, Rodolfo A; Karmonik, Christof; Boone, Timothy B et al. (2017) Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis. BMJ Open 7:e013225
High, Rachel; Kavanagh, Alex; Khavari, Rose et al. (2017) Outcomes in Pelvic Organ Prolapse Surgery in Women Using Chronic Antithrombotic Therapy. Female Pelvic Med Reconstr Surg 23:372-376
Martinez, Laura; Khavari, Rose (2017) New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women. Curr Bladder Dysfunct Rep 12:291-297
Khavari, Rose; Karmonik, Christof; Shy, Michael et al. (2017) Functional Magnetic Resonance Imaging with Concurrent Urodynamic Testing Identifies Brain Structures Involved in Micturition Cycle in Patients with Multiple Sclerosis. J Urol 197:438-444
Bekheirnia, Mir Reza; Bekheirnia, Nasim; Bainbridge, Matthew N et al. (2017) Whole-exome sequencing in the molecular diagnosis of individuals with congenital anomalies of the kidney and urinary tract and identification of a new causative gene. Genet Med 19:412-420
Bilgutay, Aylin N; Roth, David R; Gonzales Jr, Edmond T et al. (2016) Posterior urethral valves: Risk factors for progression to renal failure. J Pediatr Urol 12:179.e1-7
High, Rachel; Velasquez, Chelsea; Khavari, Rose (2016) Nephrogenic adenoma arising in a complex circumferential urethral diverticulum of a female patient with a history of childhood neuroblastoma and chemotherapy. Int Urogynecol J 27:1437-9
Sun, Huiying; Mediwala, Sanjay N; Szafran, Adam T et al. (2016) CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy. Horm Cancer 7:196-210

Showing the most recent 10 out of 59 publications