This application seeks support for our competing renewal application for the Multidisciplinary K12 Urologic Research (KURe) Career Development Program to the Scott Department of Urology and the Center for Reproductive Medicine at Baylor College of Medicine. The research emphasis of this program is in the areas pediatric urology/genitourinary development, steroid hormone action, stem cells genetics and lower urinary tract symptoms (LUTS). The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Administrative Director of the KURe career development program. Dr. Boone will serve as co-Director. Drs. Lipshultz, Cunningham, Gonzales, Khera, Roth, Janzen will ensure the M.D. trainees are optimally trained in the urologic subspecialty areas of men's health and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive tract biology, genetics, cell cycle control, stem cells, gene therapy and LUTS. The trainees will be M.D. and Ph.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in urology research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology/Cell Biology/Genetics/Pathology departments, a structured mentoring program with required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Most importantly, we have a strong track record of training successful physician scientists. Our long- term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research.

Public Health Relevance

This KURe K12 application will train new investigators to become clinical and basic researchers in urologic health issues. This program will offer training in both basic and clinical research to investigators to improve urologic health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK083014-07
Application #
8708847
Study Section
Special Emphasis Panel (ZDK1-GRB-R (M3))
Program Officer
Rankin, Tracy L
Project Start
2008-09-30
Project End
2018-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
7
Fiscal Year
2014
Total Cost
$479,002
Indirect Cost
$48,000
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Jorgez, Carolina J; Rosenfeld, Jill A; Wilken, Nathan R et al. (2014) Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1. PLoS One 9:e107028
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Tannour-Louet, Mounia; Han, Shuo; Louet, Jean-Francois et al. (2014) Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med 20:715-24
Kovac, Jason R; Pan, Michael M; Lipshultz, Larry I et al. (2014) Current state of practice regarding testosterone supplementation therapy in men with prostate cancer. Steroids 89:27-32
Hwang, Kathleen; Lamb, Dolores J (2013) The sperm penetration assay for the assessment of fertilization capacity. Methods Mol Biol 927:103-11
Bolt, Michael J; Stossi, Fabio; Newberg, Justin Y et al. (2013) Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses. Nucleic Acids Res 41:4036-48
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Slattery, Scott D; Newberg, Justin Y; Szafran, Adam T et al. (2012) A framework for image-based classification of mitotic cells in asynchronous populations. Assay Drug Dev Technol 10:161-78

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