Yale University School of Medicine and the Yale Pediatric Endocrinology Section are seeking to be one of the centers of excellence in diabetes career development that will allow young pediatric endocrinologists to establish academic careers as independent investigators in diabetes research. In this K12 application, we are requesting ~2 Physician Scientist stipends per year for 5 years. Yale has an impressive array of resources that will support this program, including the research services and research facilities provided by the CTSA-supported Yale Center for Clinical Investigation (YCCI), DERC, Magnetic Resonance Research Center, the PET Center, the Keck Biotechnology Laboratory, Mouse Metabolic Phenotyping Center and a host of other research cores. The Program Director, Assistant Program Director and faculty mentors are highly respected and productive investigators with extensive peer-reviewed grant support to fund trainees'projects and they play key administrative roles in the management of many of the most relevant research resources and facilities. Our faculty members have a long history of extensive collaborations and an outstanding track record in the career development of young physician scientists. The faculty includes three of our former K12 scholars who have developed into outstanding young investigators. Our physician scientist scholars can choose between four major areas of research training (T1D Therapeutics, Obesity/T2 DM, Immunobiology of T1D and Hypoglycemia/ Neurobiology) and 5-8 potential mentors within each area. The K12 Advisory Committee will be comprised of each of the leaders of theses research areas, along with several other senior faculty members in Pediatrics. A centerpiece of our educational program is the Yale Investigative Medicine Program (IMP). IMP offers courses that are part of the Masters Degree in Health Science Research Program curriculum in which all of our scholars who do not have an advanced degree will enroll. Our first two projected K12 scholars are on track to receive IMP PhD's in clinical investigation in 2011.

Public Health Relevance

The Yale K12 Career Development Program is designed to address the marked shortage of young pediatric endocrinologists who are trained and have the skills to develop into outstanding independent investigators in pediatric diabetes research. Yale University School of Medicine (and its Section of Pediatric Endocrinology) is an optimal site for this program, since it has the research resources;the program leadership;the educational curricula;a strong commitment to program goals;an outstanding group of internationally acclaimed senior scientists with established tract records for developing young investigators and access to superior scholar candidates

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZDK1-GRB-C (O2))
Program Officer
Hyde, James F
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Yale University
Schools of Medicine
New Haven
United States
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Sherr, Jennifer L; Patel, Neha S; Michaud, Camille I et al. (2016) Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide. Diabetes Care 39:1127-34
Van Name, Michelle A; Camp, Anne W; Magenheimer, Elizabeth A et al. (2016) Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 39:525-31
Van Name, Michelle; Giannini, Cosimo; Santoro, Nicola et al. (2015) Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance. Obesity (Silver Spring) 23:653-61
Jastreboff, Ania M; Lacadie, Cheryl; Seo, Dongju et al. (2014) Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity. Diabetes Care 37:3061-8
Sherr, Jeremy; Quirk, Tina; Tournier, Alexander L (2014) Do Homeopathic Pathogenetic Trials generate recognisable and reproducible symptom pictures?: Results from a pilot pathogenetic trial of Ozone 30c. Homeopathy 103:108-12
Sherr, Jennifer L; Ghazi, Tara; Wurtz, Anna et al. (2014) Characterization of residual * cell function in long-standing type 1 diabetes. Diabetes Metab Res Rev 30:154-62
Arbelaez, Ana Maria; Xing, Dongyuan; Cryer, Philip E et al. (2014) Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes 15:127-34
Ghazi, Tara; Rink, Linda; Sherr, Jennifer L et al. (2014) Acute metabolic effects of exenatide in patients with type 1 diabetes with and without residual insulin to oral and intravenous glucose challenges. Diabetes Care 37:210-6
Sherr, Jennifer L; Palau Collazo, Miladys; Cengiz, Eda et al. (2014) Safety of nighttime 2-hour suspension of Basal insulin in pump-treated type 1 diabetes even in the absence of low glucose. Diabetes Care 37:773-9
Sherr, Jennifer; Tsalikian, Eva; Fox, Larry et al. (2014) Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis. Diabetes Care 37:1741-4

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