Yale University School of Medicine and the Yale Pediatric Endocrinology Section are seeking to continue to be one of the centers of excellence in diabetes career development that will allow young pediatric endocrinologists to establish academic careers as independent investigators in diabetes research. In this K12 renewal application, we are requesting ~2 Physician Scientist stipends per year for 5 years. Yale has an impressive array of resources that will support this program, including the research services and research facilities provided by the CTSA-supported Yale Center for Clinical Investigation (YCCI), the Diabetes Research Center (DRC) Cores, Magnetic Resonance Research Center, PET Center, the Keck Biotechnology Laboratory, Mouse Metabolic Phenotyping Center and a host of other research cores. The Program Director, Assistant Program Director and senior faculty mentors are highly respected and productive investigators with extensive peer-reviewed grant support to fund trainees' projects and they play key administrative roles in the management of many of the most relevant research resources and facilities. Our faculty members have a long history of extensive collaborations and an outstanding track record in the career development of young physician scientists. The faculty includes four of our former K12 scholars who have developed into outstanding independent investigators. Our K12 scholars can choose between 5 major areas of research training (Artificial Pancreas/Diabetes Technology/T1D Therapeutics; T1 and T2D Clinic Registries and Clinic Networks; Obesity/T2 DM; Immunobiology of T1D and Hypoglycemia/Neurobiology) with 5-8 potential mentors within each area. The K12 Advisory Committee will be comprised of each of the leaders of theses research areas, along with several other senior faculty members in Pediatrics. A centerpiece of our educational program is the Yale Investigative Medicine PhD Program and the internal pipeline of current post-doctoral fellows includes two T32 trainees who are enrolled in the Investigative Medicine PhD program. The Investigative Medicine Program also offers courses that are part of the Masters Degree in Health Science Research Program curriculum in which all of our K12 scholars who do not have an advanced degree will be encouraged to enroll. All of our K12 scholars will received comprehensive instruction regarding the responsible conduct of research and we will make every possible effort to attract qualified minority candidates.

Public Health Relevance

The Yale K12 Program is seeking to continue its efforts to address the marked shortage of young pediatric endocrinologists who are trained and have the skills to develop into the next generation of outstanding independent investigators in pediatric diabetes research. Yale School of Medicine (and its section of Pediatric Endocrinology) is an optimal site for this program, since it has a broad array of research resources; renowned program leaders who are strongly committed to program goals; an exceptional education curricula; an outstanding group of program faculty who are internationally acclaimed for their research accomplishments; and an excellent track record of success in supporting the career development of prior K12 appointees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK094714-07
Application #
9297289
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Spain, Lisa M
Project Start
2011-09-16
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Van Name, Michelle A; Hilliard, Marisa E; Boyle, Claire T et al. (2018) Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes. Pediatr Diabetes 19:114-120
Erie, Christine; Van Name, Michelle A; Weyman, Kate et al. (2018) Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings. Pediatr Diabetes 19:92-97
Patel, Neha S; Van Name, Michelle A; Cengiz, Eda et al. (2017) Altered Patterns of Early Metabolic Decompensation in Type 1 Diabetes During Treatment with a SGLT2 Inhibitor: An Insulin Pump Suspension Study. Diabetes Technol Ther 19:618-622
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Jastreboff, Ania M; Sinha, Rajita; Arora, Jagriti et al. (2016) Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes 65:1929-39
Van Name, Michelle A; Camp, Anne W; Magenheimer, Elizabeth A et al. (2016) Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 39:525-31
Patel, Neha S; Van Name, Michelle A; Cengiz, Eda et al. (2016) Mitigating Reductions in Glucose During Exercise on Closed-Loop Insulin Delivery: The Ex-Snacks Study. Diabetes Technol Ther 18:794-799
Sherr, Jennifer L; Patel, Neha S; Michaud, Camille I et al. (2016) Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide. Diabetes Care 39:1127-34

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