The goal of this Career Development Program is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative, scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children. The need for this Program derives from the critical shortage of academic pediatric endocrinologists working in diabetes research, which has been emphasized by organizations such as the American Diabetes Association, Juvenile Diabetes Research Foundation, and Pediatric Academic Societies. In addition, this Program recognizes the important new opportunities for advancing diabetes research in children provided by such pivotal scientific advances as the Human Genome Project, and improved success in islet transplantation and the production of biomechanical and bio-engineered islets. This K12 Program will support Scholars for up to 3 years of research career development at the junior faculty level. The Program faculty includes 32 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials, active research programs and training records. These mentors will supervise Scholars'career development through basic laboratory and/or patient- oriented research related to diabetes in children. Career development opportunities will include 3 major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action;2) Regulation of Pancreatic beta-Cell Function and Development;and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation;2) Therapeutic Approaches to Islet Cell Preservation 3) Obesity and Insulin Resistance, 4) Diabetes Complications;and 5) Diabetes Epidemiology and Biostatistics. The Program includes a curriculum of formal training in all aspects of research;(including biostatistics, bioethics, molecular biology, etc.) and is strongly supported by access to a superb range of institutional resources, including the CHOP CTRC and the UPenn DERC.

Public Health Relevance

In the United States, medical research progress in pediatric diabetes has been hampered by a shortage of physicians who are trained to perform patient- oriented and laboratory-based research related to diabetes in children. The Children's Hospital of Philadelphia has consistently produced highly skilled researchers in pediatric diabetes and related conditions. This grant will provide funds to support promising young physicians as they develop the skills needed to become successful in their field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK094723-04
Application #
8715797
Study Section
Special Emphasis Panel (ZDK1-GRB-C (O2))
Program Officer
Hyde, James F
Project Start
2011-09-16
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
$349,470
Indirect Cost
$25,887
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tharakan, Sasha J; Subotic, Ulrike; Kalisch, Markus et al. (2016) Compartment Pressures in Children With Normal and Fractured Forearms: A Preliminary Report. J Pediatr Orthop 36:410-5
Henley, Kathryn D; Stanescu, Diana E; Kropp, Peter A et al. (2016) Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function. Cell Rep 15:2637-50
Roizen, Jeffrey D; Danzig, Jennifer; Groleau, Veronique et al. (2016) Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clin Endocrinol Metab 101:880-8
Thacher, Tom D; Fischer, Philip R; Singh, Ravinder J et al. (2015) CYP2R1 Mutations Impair Generation of 25-hydroxyvitamin D and Cause an Atypical Form of Vitamin D Deficiency. J Clin Endocrinol Metab 100:E1005-13
Mitchell, Jonathan A; Chesi, Alessandra; Elci, Okan et al. (2015) Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions. J Bone Miner Res 30:1676-83
Stanescu, Diana E; Hughes, Nkecha; Patel, Puja et al. (2015) A novel mutation in GATA6 causes pancreatic agenesis. Pediatr Diabetes 16:67-70
Paley, Grace L; Sheldon, Claire A; Burrows, Evanette K et al. (2015) Overweight and obesity in pediatric secondary pseudotumor cerebri syndrome. Am J Ophthalmol 159:344-52.e1
Li, Dong; Weber, David R; Deardorff, Matthew A et al. (2015) Exome sequencing reveals a nonsense mutation in MMP13 as a new cause of autosomal recessive metaphyseal anadysplasia. Eur J Hum Genet 23:264-6
McCormack, Shana; Polyak, Erzsebet; Ostrovsky, Julian et al. (2015) Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans. Mitochondrion 22:45-59
Weber, David R; Haynes, Kevin; Leonard, Mary B et al. (2015) Type 1 diabetes is associated with an increased risk of fracture across the life span: a population-based cohort study using The Health Improvement Network (THIN). Diabetes Care 38:1913-20

Showing the most recent 10 out of 42 publications