Environmental exposures play a critical role in the pathogenesis of many common complex diseases. The purpose of the proposed Vanderbilt Environmental Health Science Scholars (VEHSS) program is to develop patient-oriented researchers committed to a career in environmental health research and equipped to function within and lead multidisciplinary teams of researchers to enhance understanding of environmental disease and to improve health. The VEHSS will focus on two specific scientific themes: 1) the role of oxidative stress in environmental injury/exposure and 2) mechanisms of environmental neurotoxicity. Vanderbilt investigators have developed and validated unique biomarkers of oxidative stress, a process implicated in the pathogenesis of many common diseases. Likewise, Vanderbilt investigators have elucidated mechanisms of metal transport and oxidative stress to better understand adverse developmental and neurodegenerative effects of environmental exposures. In each focus area of patient-oriented environmental health sciences research, Scholars will be trained in 1) a multidisciplinary approach, drawing on expertise in human genetics to identify gene-environment interactions, 2) proteomics, lipidomics, and state-of-the-art mass spectrometry techniques to discover biomarkers of environmental exposure and disease states, 3) cutting-edge imaging techniques to analyze tissue uptake of metal ions and toxins and local metabolic consequences, and 4) informatics and biostatistics to analyze large and complex data. The current proposal provides a unique opportunity to merge Vanderbilt's strengths in basic environmental health sciences research and patient oriented research to create a training program that can have a major impact on environmental health in the United States. Thus the goals of the VEHSS program are to: 1) Integrate Vanderbilt's well-established, strong basic science programs in toxicology and environmental health sciences with its equally significant accomplishments in patient-oriented research to increase the impact of environmental health sciences research to improve human health. 2) Develop a unique didactic core in research methodology for conducting hypothesis-driven research in environmental health and capitalize on existing career development resources to develop a cadre of leaders in multidisciplinary patient-oriented research in environmental health sciences. 3) Leverage the shared resources of the Vanderbilt-Meharry Alliance to increase the number of underrepresented minorities serving as Scholars and Mentors and leaders in environmental health sciences research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12ES015855-05
Application #
8137255
Study Section
Special Emphasis Panel (ZES1-SET-A (K2))
Program Officer
Shreffler, Carol K
Project Start
2007-09-01
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$752,306
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Price, Catherine C; Garvan, Cynthia; Hizel, Loren P et al. (2017) Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery. J Alzheimers Dis 59:1027-1035
Dunn, Julia P; Abumrad, Naji N; Kessler, Robert M et al. (2017) Caloric Restriction-Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration. Obesity (Silver Spring) 25:1910-1915
Sloan, Chantel D; Gebretsadik, Tebeb; Rosas-Salazar, Christian et al. (2016) Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death. PLoS One 11:e0158521
Billings 4th, Frederic T; Hendricks, Patricia A; Schildcrout, Jonathan S et al. (2016) High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA 315:877-88
Van Driest, Sara L; McGregor, Tracy L; Velez Edwards, Digna R et al. (2015) Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. PLoS One 10:e0127791
Jering, Karola; Aschner, Michael; Beller, Amy et al. (2015) Parenteral nutrition as an unexpected and preventable source of mercury exposure in preterm infants. J Pediatr 166:1533-5
Wu, Pingsheng; Larkin, Emma K; Reiss, Sara S et al. (2015) ?2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study. BMC Med Genet 16:82
Nechuta, Sarah; Cai, Qiuyin; Zheng, Ying et al. (2014) Urinary biomarkers of oxidative stress and breast cancer survival. Cancer Causes Control 25:701-7
Savage, Shane W; Zald, David H; Cowan, Ronald L et al. (2014) Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity. Obesity (Silver Spring) 22:1452-7
Miller, E Kathryn; Gebretsadik, Tebeb; Carroll, Kecia N et al. (2013) Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years. Pediatr Infect Dis J 32:950-5

Showing the most recent 10 out of 33 publications