The extraordinary growth and specialization that has occurred over the past several decades in the sciences has made it increasingly difficult to link the increasing divide between clinical and basic science components of ophthalmic and vision sciences. The less-than-optimal degree of cross-talk between scientists engaged in studying fundamental biological processes and clinicians providing care to patients has had multiple deleterious effects. Continued external factors are expected to impact this trend negatively for the foreseeable future. Traditional approaches, based purely on didactic curricula, to """"""""teach"""""""" basic sciences to highly-trained clinicians are only variably effective as they offer limited opportunity to these clinicians for hands-on experience in designing and conducting studies. Additionally, many clinicians engaged in pure clinical (vs. bench-based) research have had very limited formal training in methodological aspects of clinical study design and execution. The Harvard Department of Ophthalmology is one of the leading and largest academic departments of Ophthalmology in the nation and a major recipient of NIH funding. With 113 full-time clinical and basic science faculty, it continues to make significant contributions to ophthalmic and vision research in virtually all basic, applied, and clinical subspecialty areas. The Harvard-Vision Clinical Scientist Development Program proposes to offer a customized and structured learning, research, and development environment to a select group of qualified clinically trained candidates who have recently completed (or about to complete) their training, but who desire further mentored learning experience so as to become independent leading clinical scientists in their respective fields. Trainees in this program will (i) complete a core curriculum that will include the Harvard Program in Clinical effectiveness (PCE) - a summer-long immersion program in biostatistics, epidemiology, study design, and outcomes measurement. Additional required curricular activities will include the Harvard Medical School course, Neurobiology 300 """"""""Biologic Bases of Ophthalmic Disease"""""""", a multidisciplinary survey course focusing on the biological mechanisms (genetics, immunology, neuroscience, vascular biology) of eye disease. Candidates will also (ii) perform research in a closely mentored program under the guidance of lead mentors who are leaders in their respective fields with the express objective of allowing them to develop into independent investigators. Trainees in this program will additionally have the option of seeking an advanced degree (MS, MPH, PhD, ScD) at Harvard.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12EY016335-05
Application #
7497865
Study Section
Special Emphasis Panel (ZEY1-VSN (04))
Program Officer
Agarwal, Neeraj
Project Start
2004-09-30
Project End
2010-03-31
Budget Start
2008-09-30
Budget End
2010-03-31
Support Year
5
Fiscal Year
2008
Total Cost
$583,096
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
Yin, Jia; Jurkunas, Ula (2018) Limbal Stem Cell Transplantation and Complications. Semin Ophthalmol 33:134-141
Houston, Kevin E; Bowers, Alex R; Peli, Eli et al. (2018) Peripheral Prisms Improve Obstacle Detection during Simulated Walking for Patients with Left Hemispatial Neglect and Hemianopia. Optom Vis Sci 95:795-804
Harris, Deshea L; Yamaguchi, Takefumi; Hamrah, Pedram (2018) A Novel Murine Model of Radiation Keratopathy. Invest Ophthalmol Vis Sci 59:3889-3896
Houston, Kevin E; Tomasi, Matteo; Amaral, Christina et al. (2018) The Magnetic Levator Prosthesis for Temporary Management of Severe Blepharoptosis: Initial Safety and Efficacy. Transl Vis Sci Technol 7:7
Margeta, Milica A; Lad, Eleonora M; Proia, Alan D (2018) CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. Graefes Arch Clin Exp Ophthalmol 256:2449-2456
Cope, Jennifer R; Konne, Nuadum Muriel; Jacobs, Deborah S et al. (2018) Corneal Infections Associated with Sleeping in Contact Lenses - Six Cases, United States, 2016-2018. MMWR Morb Mortal Wkly Rep 67:877-881
Whitman, Mary C; Nguyen, Elaine H; Bell, Jessica L et al. (2018) Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis. Invest Ophthalmol Vis Sci 59:5201-5209
Houston, Kevin E; Peli, Eli; Goldstein, Robert B et al. (2018) Driving With Hemianopia VI: Peripheral Prisms and Perceptual-Motor Training Improve Detection in a Driving Simulator. Transl Vis Sci Technol 7:5
Comander, Jason; Weigel-DiFranco, Carol; Maher, Matthew et al. (2017) The Genetic Basis of Pericentral Retinitis Pigmentosa-A Form of Mild Retinitis Pigmentosa. Genes (Basel) 8:
Huckfeldt, Rachel M; Comander, Jason (2017) Management of Cystoid Macular Edema in Retinitis Pigmentosa. Semin Ophthalmol 32:43-51

Showing the most recent 10 out of 85 publications