The University of California at San Diego (UCSD) and San Diego State University (SDSU) propose to continue a successful institutional research and academic career development award (IRACDA) program for postdoctoral scholars. Six trainees will enter each year for a 3-year training period. The San Diego IRACDA Program will recruit and train under-represented postdoctoral fellows in top research labs, coupling mentored research with focused training in teaching, research ethics, grant writing, lab management, and a variety of professorial skills. The immediate goals are to help these postdocs begin independent research careers with appropriate skills to succeed, and to place IRACDA Fellows in tenure track jobs within the UC and California State University systems. The long-term goal is to increase the number of under-represented faculty and faculty committed to the education of URMs nation-wide. Research training will occur primarily at UCSD, and will include weekly lab meetings, departmental seminars, evaluated research presentations, monthly meetings with the PI, a course in research ethics, courses in grant and paper writing, and annual attendance at a national meeting (poster presentations in years 2 and 3) and the National IRACDA meeting. These activities will be coordinated by Drs. Brunton and Villarreal. Teaching will occur at SDSU, under the coordination of Dr. Pozos, in a design that keeps the emphasis on continual research progress. Following a six month period in the lab to establish their research, fellows will prepare &deliver 3 lectures per semester in a beginning biology course for 5 semesters, with training in classroom management, advising, assessment, e-curriculum development, and development of individual teaching styles. The academic emphasis is on mammalian systems biology, which also expands the Fellows' knowledge, since many of them have specialized without comprehensive training in biology. Expectations are substantial esprit de corps amongst Fellows, a major publication during year two, a research grant in draft form by the second half of year three, a portfolio of exemplary lectures by the end of year three, and a more advanced position or job offer at the end of year three. Fellows will be followed for ten years from the start of the program (roughly to the time of a tenure decision) and their progress compared to that of the general pool of postdoctoral fellows on the two campuses, majority postdocs in the San Diego IRACDA, other postdoctoral fellows in the same labs, and, as data become available, the national pool of NIH-supported postdocs.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Singh, Shiva P
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Heinrichsen, Erilynn T; Zhang, Hui; Robinson, James E et al. (2014) Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab 3:42-54
Phelan, Vanessa V; Moree, Wilna J; Aguilar, Julieta et al. (2014) Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. J Bacteriol 196:1683-93
Döhrmann, Simon; Anik, Sabina; Olson, Joshua et al. (2014) Role for streptococcal collagen-like protein 1 in M1T1 group A Streptococcus resistance to neutrophil extracellular traps. Infect Immun 82:4011-20
Sproul, Andrew A; Jacob, Samson; Pre, Deborah et al. (2014) Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. PLoS One 9:e84547
Xu, Meimei; Hillwig, Matthew L; Lane, Amy L et al. (2014) Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. J Nat Prod 77:2144-7
Tagliabracci, Vincent S; Engel, James L; Wiley, Sandra E et al. (2014) Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A 111:5520-5
Verkaar, Folkert; van Offenbeek, Jody; van der Lee, Miranda M C et al. (2014) Chemokine cooperativity is caused by competitive glycosaminoglycan binding. J Immunol 192:3908-14
Kawamura, Tetsuya; Stephens, Bryan; Qin, Ling et al. (2014) A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One 9:e81454
Moree, Wilna J; McConnell, Oliver J; Nguyen, Don D et al. (2014) Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol 9:2300-8
Franks, Sarah E; Ebrahimi, Celia; Hollands, Andrew et al. (2014) Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun 82:1132-40

Showing the most recent 10 out of 51 publications