This is a competitive renewal application for continued support under new leadership, for the Reproductive Scientist Development Program (RSDP), a multi-disciplinary, multi-institutional research career development program for obstetrician-gynecologists in cell and molecular biology and related fundamental sciences. The objective of this program is to educate obstetrician-gynecologists in contemporary basic science research related to reproductive medicine and biology in order to prepare them for research careers in academic medicine. The overall goal is to help ensure that academic obstetrics and gynecology fulfills its mission to increase research and discovery in the reproductive sciences. Outstanding MD/PhD, PhD, and MD scientists with broad research experience serve as faculty mentors. A unique feature of this program is that outstanding individuals, upon completing a residency in obstetrics and gynecology, and in many cases two or three years of clinical subspecialty fellowship, spend two to three years (Phase I) in fundamental science research laboratories under the supervision and mentorship of experienced, highly regarded accomplished scientists. During Phase I, Scholars are dedicated to full-time research with no clinical obligations. Following this experience, Scholars spend an additional three-year period establishing their research program in a Department of Obstetrics and Gynecology (Phase II). Here, the Scholar serves as a junior faculty member with at least 75% time devoted to developing an independent research career. Historically, Phase I has been entirely funded by NICHD and Phase II has been funded from a number of possible sources, including NIH an private grants, and from contributions to the RSDP program from the obstetrics and gynecologic societies, from philanthropic foundation, industry, departmental, and other sources. This funding mechanism will continue, however, NIH funding will support up to 3 Scholars for the duration of Phase I and Phase II. Upon completion of this program, the Scholar is expected to continue to pursue a career as a productive physician-scientist investigator. This program serves as a model to education increased numbers of reproductive scientists to develop into leaders in academic Departments of Obstetrics and Gynecology, and this is now occurring.

Public Health Relevance

The Reproductive Scientist Development Program plan for career development serves as a model for postgraduate medical education, and assures that some of the most promising young physician-investigators in the country will remain in academic investigative obstetrics and gynecology. A great majority of the Scholars who have finished Phase II of the Program have dedicated themselves to research in the reproductive sciences and have developed major independent funding support. To date their productivity has been outstanding, has contributed greatly to the reproductive sciences, and is a credit for the Program.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHD1)
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Lamar, Charisee A
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Washington University
Obstetrics & Gynecology
Schools of Medicine
Saint Louis
United States
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Sandgren, Jeremy A; Santillan, Mark K; Grobe, Justin L (2016) Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. Hypertension 67:1119-20
Mainigi, Monica; Rosenzweig, Jason M; Lei, Jun et al. (2016) Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes. Reprod Sci 23:785-94
Kempuraj, Duraisamy; Thangavel, Ramasamy; Fattal, Ranan et al. (2016) Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)). Neurochem Res 41:1042-9
Edlow, Andrea G; Guedj, Faycal; Pennings, Jeroen L A et al. (2016) Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity. Am J Obstet Gynecol 214:623.e1-623.e10
Wallenstein, Matthew B; Jelliffe-Pawlowski, Laura L; Yang, Wei et al. (2016) Inflammatory biomarkers and spontaneous preterm birth among obese women. J Matern Fetal Neonatal Med 29:3317-22
Wesselink, Amelia K; Wise, Lauren A; Rothman, Kenneth J et al. (2016) Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort. Reprod Toxicol 62:39-45
Devor, Eric J; Schickling, Brandon M; Reyes, Henry D et al. (2016) Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncol Rep 35:2461-5
Ulrich, Victoria; Gelber, Shari E; Vukelic, Milena et al. (2016) ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Arthritis Rheumatol 68:730-9
Gonzalez-Rodriguez, Pablo; Cantu, Jessica; O'Neil, Derek et al. (2016) Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR). Am J Obstet Gynecol 214:625.e1-625.e11
Wesselink, Amelia K; Wise, Lauren A; Hatch, Elizabeth E et al. (2016) Menstrual cycle characteristics and fecundability in a North American preconception cohort. Ann Epidemiol 26:482-487.e1

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