This renewal application seeks NICHD support for 6 first-year, 6 second-year, and 5 third-year positions in the Pediatric Scientist Development Program (PSDP), a career development pathway for pediatric fellows from which 156 physician-scientists have graduated since 1987. The objectives of the program remain unchanged since its inception: (a) to recruit pediatricians whose outstanding potential as scientists can be developed by senior research mentors and (b) to expand the cadre of superbly trained pediatric physician-scientists, who will catalyze cutting-edge discoveries in child health and lead the pediatric departments of the future. Research activities occur in basic, translational, or clinical investigation;in epidemiology and biostatistics;in health services research;or in any other discipline relevant to the NICHD mission. Unique aspects of the PSDP include its national scope for recruitment of fellows and mentors, its intensive focus on career development during fellowship, its supra- institutional governance under the aegis of the Association of Medical School Pediatric Department Chairs (AMSPDC), its emphasis on research environments outside departments of pediatrics, and its multifaceted approach to mentoring that encompasses scientific mentors, PSDP committees, and pediatric department chairs. A Steering Committee, meeting biannually, sets programmatic policy;a Selection Committee interviews PSDP candidates;and an independent Program Evaluation Committee measures the program's effectiveness in ensuring fellows'success. A centerpiece of the PSDP is the annual career development curriculum that convenes PSDP fellows, advisory committees, and all US and Canadian pediatric department chairs at the AMSPDC meeting. Currently, PSDP graduates occupy faculty positions in more than 60 pediatric departments and their affiliates across North America. PSDP graduates have served as PIs on more than 160 NIH R, P, U, and K awards, of which 42% are currently active. Since 1987, the person success rate for PSDP graduates who apply for NIH R01 funding is 51%. Graduates now serve as pediatric department chairs, HHMI investigators, institute leaders, and division directors. Over its 25-year history, the PSDP has implemented a national strategy to expand the boundaries of child health research, to develop the research careers of rigorously trained pediatric physician- scientists, and to produce the next generation of investigative leaders in pediatrics.
As the percentage of children in the US population surpasses 20%, pediatric diseases such as prematurity, infections, asthma, obesity, and childhood cancer claim an ever- greater share of the public health burden. The Pediatric Scientist Development Program provides pediatricians with the scientific training to discover the causes and cures of childhood illness.
|Priest, James R; Ceresnak, Scott R; Dewey, Frederick E et al. (2014) Molecular diagnosis of long QT syndrome at 10 days of life by rapid whole genome sequencing. Heart Rhythm 11:1707-13|
|Bates, John T; Keefer, Christopher J; Slaughter, James C et al. (2014) Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein. Virology 454-455:139-44|
|DeBosch, Brian J; Kluth, Oliver; Fujiwara, Hideji et al. (2014) Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun 5:4642|
|Li, Fang; Downing, Brandon D; Smiley, Lucy C et al. (2014) Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo. Circulation 129:1213-24|
|Debosch, Brian J; Chen, Zhouji; Saben, Jessica L et al. (2014) Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem 289:10989-98|
|Tran, Cindy S; Eran, Yoni; Ruch, Travis R et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe 15:636-43|
|Priest, James R; Nead, Kevin T; Wehner, Mackenzie R et al. (2014) Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. PLoS One 9:e88972|
|Stansfield, Brian K; Bessler, Waylan K; Mali, Raghuveer et al. (2014) Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation. Am J Pathol 184:79-85|
|Tran, Cindy S; Rangel, Stephanie M; Almblad, Henrik et al. (2014) The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier. PLoS Pathog 10:e1004479|
|Bucior, Iwona; Tran, Cindy; Engel, Joanne (2014) Assessing Pseudomonas virulence using host cells. Methods Mol Biol 1149:741-55|
Showing the most recent 10 out of 182 publications