The primary purpose of the CHRCDA program at the Children's National Medical Center/Children's Research is to facilitate the development of successful basic science/translational research careers of junior faculty members in pediatrics. The rationale for this program is that while there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances. Yet, extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need. It provides time for junior pediatrician investigators to: 1) take coursework in basic science areas relevant to their research;2) learn state-of-the art laboratory methodology;3) develop preliminary data under the supervision of an established investigator that will lead to submission of an independent NIH grant application;and 4) learn to effectively translate their accomplishments in pediatric research to the improvement of child health. In order to accomplish this goal the CHRCDA Scholars will spend at least 75% effort honing these skills over a 2-5 year period of time, depending on past experience and topic area. During this period each of the above areas is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of an Established Investigator/Mentor. We propose 15 mentors in 4 affinity areas: neuroscience, genetics, molecular physiology, and cell biology. The administrative structure of the CHRCDA includes a Principal Investigator/Program Director of the CHRCDA Center, a Training Director, a Director of Minority Recruitment and internal and external advisory committees. We propose to select and train a total of 8 CHRCDA Scholars at the Assistant Professor level during the grant period.

Public Health Relevance

of the Child Health Research Center Development Award Program at CNMC is to train the next generation of pediatrician scientists who will perform cutting edge research into issues of importance to child health. While there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances, and extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need by providing 2-5 years of training and experience under the direction of an experienced investigator-mentor.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001399-13
Application #
8402156
Study Section
Special Emphasis Panel (ZHD1-DSR-N (12))
Program Officer
Winer, Karen
Project Start
2001-09-25
Project End
2015-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
13
Fiscal Year
2013
Total Cost
$274,519
Indirect Cost
$32,000
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Restrepo-Gualteros, S M; Rodriguez-Martinez, C E; Jaramillo-Barberi, L E et al. (2015) Adolescent form of sporadic lymphangioleiomyomatosis (S-LAM). Allergol Immunopathol (Madr) 43:111-4
Rodríguez-Martínez, Carlos E; Melo-Rojas, Andrea; Restrepo-Gualteros, Sonia M et al. (2014) Validation of the Spanish version of the childhood asthma control test (cACT) in a population of Hispanic children. J Asthma 51:855-62
Rodríguez-Martínez, Carlos E; Nino, Gustavo; Castro-Rodriguez, Jose A (2014) Validation of the Spanish version of the Test for Respiratory and Asthma Control in Kids (TRACK) in a population of Hispanic preschoolers. J Allergy Clin Immunol Pract 2:326-31.e3
Pillai, Dinesh K; Sankoorikal, Binu-John V; Johnson, Eric et al. (2014) Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium. Am J Respir Cell Mol Biol 50:292-300
Kornegay, Joe N; Spurney, Christopher F; Nghiem, Peter P et al. (2014) Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J 55:119-49
Restrepo-Gualteros, Sonia M; Jaramillo-Barberi, Lina E; Gonzalez-Santos, Monica et al. (2014) Characterization of cytomegalovirus lung infection in non-HIV infected children. Viruses 6:2038-51
Perez, Geovanny F; Pancham, Krishna; Huseni, Shehlanoor et al. (2014) Rhinovirus infection in young children is associated with elevated airway TSLP levels. Eur Respir J 44:1075-8
Tuchman, Shamir; Asico, Laureano D; Escano, Crisanto et al. (2013) Development of an animal model of nephrocalcinosis via selective dietary sodium and chloride depletion. Pediatr Res 73:194-200
Payne, Asha S; Freishtat, Robert J (2012) Conserved steroid hormone homology converges on nuclear factor ?B to modulate inflammation in asthma. J Investig Med 60:13-7
Spurney, Christopher F; Sali, Arpana; Guerron, Alfredo D et al. (2011) Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. J Cardiovasc Pharmacol Ther 16:87-95

Showing the most recent 10 out of 27 publications