The primary purpose of the CHRCDA program at the Children's National Medical Center/Children's Research is to facilitate the development of successful basic science/translational research careers of junior faculty members in pediatrics. The rationale for this program is that while there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances. Yet, extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need. It provides time for junior pediatrician investigators to: 1) take coursework in basic science areas relevant to their research;2) learn state-of-the art laboratory methodology;3) develop preliminary data under the supervision of an established investigator that will lead to submission of an independent NIH grant application;and 4) learn to effectively translate their accomplishments in pediatric research to the improvement of child health. In order to accomplish this goal the CHRCDA Scholars will spend at least 75% effort honing these skills over a 2-5 year period of time, depending on past experience and topic area. During this period each of the above areas is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of an Established Investigator/Mentor. We propose 15 mentors in 4 affinity areas: neuroscience, genetics, molecular physiology, and cell biology. The administrative structure of the CHRCDA includes a Principal Investigator/Program Director of the CHRCDA Center, a Training Director, a Director of Minority Recruitment and internal and external advisory committees. We propose to select and train a total of 8 CHRCDA Scholars at the Assistant Professor level during the grant period.
of the Child Health Research Center Development Award Program at CNMC is to train the next generation of pediatrician scientists who will perform cutting edge research into issues of importance to child health. While there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances, and extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need by providing 2-5 years of training and experience under the direction of an experienced investigator-mentor.
|Gutierrez, Maria J; Gomez, Jose L; Perez, Geovanny F et al. (2016) Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLoS One 11:e0162244|
|Pancham, Krishna; Sami, Iman; Perez, Geovanny F et al. (2016) Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity. Pediatr Neonatol 57:27-34|
|Naik, Swati; Nicholas, Sarah K; Martinez, Caridad A et al. (2016) Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes. J Allergy Clin Immunol 137:1498-1505.e1|
|Aragona, Elena; El-Magbri, Eussra; Wang, Justin et al. (2016) Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus. Hosp Pediatr 6:211-8|
|McLaughlin, Lauren P; Lang, Haili; Williams, Elizabeth et al. (2016) Human parainfluenza virus-3 can be targeted by rapidly ex vivo expanded T lymphocytes. Cytotherapy 18:1515-1524|
|Abraham, Allistair; Jacobsohn, David A; Bollard, Catherine M (2016) Cellular therapy for sickle cell disease. Cytotherapy 18:1360-1369|
|Clarridge, Katherine; Leitenberg, David; Loechelt, Brett et al. (2016) Major Histocompatibility Complex Class II Deficiency due to a Novel Mutation in RFXANK in a Child of Mexican Descent. J Clin Immunol 36:4-5|
|Nino, Gustavo; Govindan, R B; Al-Shargabi, Tareq et al. (2016) Premature Infants Rehospitalized because of an Apparent Life-Threatening Event Had Distinctive Autonomic Developmental Trajectories. Am J Respir Crit Care Med 194:379-81|
|Perez, Geovanny F; Rodriguez-Martinez, Carlos E; Nino, Gustavo (2015) Rhinovirus-Induced Airway Disease: A Model to Understand the Antiviral and Th2 Epithelial Immune Dysregulation in Childhood Asthma. J Investig Med 63:792-5|
|Peters-Hall, Jennifer R; Brown, Kristy J; Pillai, Dinesh K et al. (2015) Quantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome. Am J Respir Cell Mol Biol 53:22-32|
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