The primary purpose of the CHRCDA program at the Children's National Medical Center/Children's Research is to facilitate the development of successful basic science/translational research careers of junior faculty members in pediatrics. The rationale for this program is that while there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances. Yet, extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need. It provides time for junior pediatrician investigators to: 1) take coursework in basic science areas relevant to their research;2) learn state-of-the art laboratory methodology;3) develop preliminary data under the supervision of an established investigator that will lead to submission of an independent NIH grant application;and 4) learn to effectively translate their accomplishments in pediatric research to the improvement of child health. In order to accomplish this goal the CHRCDA Scholars will spend at least 75% effort honing these skills over a 2-5 year period of time, depending on past experience and topic area. During this period each of the above areas is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of an Established Investigator/Mentor. We propose 15 mentors in 4 affinity areas: neuroscience, genetics, molecular physiology, and cell biology. The administrative structure of the CHRCDA includes a Principal Investigator/Program Director of the CHRCDA Center, a Training Director, a Director of Minority Recruitment and internal and external advisory committees. We propose to select and train a total of 8 CHRCDA Scholars at the Assistant Professor level during the grant period.

Public Health Relevance

of the Child Health Research Center Development Award Program at CNMC is to train the next generation of pediatrician scientists who will perform cutting edge research into issues of importance to child health. While there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances, and extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need by providing 2-5 years of training and experience under the direction of an experienced investigator-mentor.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001399-14
Application #
8598484
Study Section
Special Emphasis Panel (ZHD1-DSR-N (12))
Program Officer
Winer, Karen
Project Start
2001-09-25
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
14
Fiscal Year
2014
Total Cost
$432,000
Indirect Cost
$32,000
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Nino, Cesar L; Perez, Geovanny F; Isaza, Natalia et al. (2018) Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Sci Rep 8:5526
Megalaa, Rosemary; Perez, Geovanny F; Kilaikode-Cheruveettara, Sasikumar et al. (2018) Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification. J Investig Med 66:46-51
Gerber, Daniel; Forster, Catherine S; Hsieh, Michael (2018) The Role of the Genitourinary Microbiome in Pediatric Urology: a Review. Curr Urol Rep 19:13
Pérez-Losada, Marcos; Authelet, Kayla J; Hoptay, Claire E et al. (2018) Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas. Microbiome 6:179
Forster, Catherine S; Jackson, Elizabeth; Ma, Qing et al. (2018) Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders. Pediatr Nephrol 33:1365-1374
Rodriguez-Martinez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2018) Systematic review of instruments aimed at evaluating the severity of bronchiolitis. Paediatr Respir Rev 25:43-57
Forster, Catherine S; Shaikh, Nader; Hoberman, Alejandro et al. (2018) Uropathogens and Pyuria in Children With Neurogenic Bladders. Pediatrics 141:
Val, Stéphanie; Jeong, Stephanie; Poley, Marian et al. (2017) Purification and characterization of microRNAs within middle ear fluid exosomes: implication in otitis media pathophysiology. Pediatr Res 81:911-918
Rodríguez-Martínez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2017) A systematic review of instruments aimed at evaluating metered-dose inhaler administration technique in children. J Asthma 54:173-185
Zhao, Hui Fen; Abraham, Allistair; Kim, Yoon-Sang et al. (2017) Lentiviral Transfer of ?-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine ?-Thalassemia. Mol Ther 25:593-605

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