This is a renewal application for the continued support of the Center of Excellence in Child Health at Washington University School of Medicine. The scientific focus of our Center is to develop and utilize genetic models of human disease states in transgenic and knockout mice and zebrafish. The long term goal of our Center is to develop Scholars in human developmental biology. We shall achieve this goal by applying the recent advances in genome sciences and developmental biology to an understanding of the pathogenesis and treatment of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this, we shall combine the established areas of investigative strength of Washington University School of Medicine and the Department of Pediatrics with genome sciences and developmental biology. Our Scholar's Program, now ten years old, will ultimately close the gap between basic geneticists/genome scientists/developmental biologists and pediatric clinicians. We have in place a structure in which bright, motivated, young pediatric scientists flourish in a protected environment and will emerge as leaders in an evolving area of Pediatrics. Alan L. Schwartz, Ph.D., M.D. will serve as P.I. and Jonathan D. Gitlin, M.D. will serve as Program Director. The Center (via this award and matched funds from Washington University School of Medicine) and its Scholars will continue to utilize our institutionally-funded core facility for the generation of animal models of human disease states via new and evolving state-of-the-art technologies. The long term goals of the Center will be realized as its Scholars contribute to the development of and leadership in human developmental biology during the next two or more decades.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001487-15
Application #
7758282
Study Section
Special Emphasis Panel (ZHD1-DSR-T (27))
Program Officer
Winer, Karen
Project Start
1996-02-15
Project End
2012-11-30
Budget Start
2009-12-01
Budget End
2012-11-30
Support Year
15
Fiscal Year
2010
Total Cost
$426,861
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Zhou, Julie Y; Isaacson-Schmid, Megan; Utterson, Elizabeth C et al. (2015) Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates. Int J Infect Dis 39:50-2
Kozel, Beth A; Su, Chi-Ting; Danback, Joshua R et al. (2014) Biomechanical properties of the skin in cutis laxa. J Invest Dermatol 134:2836-8
Deady, Lauren E; Todd, Elizabeth M; Davis, Chris G et al. (2014) L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Infect Immun 82:1982-93
Kozel, Beth A; Bayliss, Susan J; Berk, David R et al. (2014) Skin findings in Williams syndrome. Am J Med Genet A 164A:2217-25
Kozel, Beth A; Danback, Joshua R; Waxler, Jessica L et al. (2014) Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1. Hypertension 63:74-9
Keppel, Molly P; Yang, Liping; Cooper, Megan A (2013) Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation. J Immunol 190:4754-62
Morley, Sharon Celeste (2013) The actin-bundling protein L-plastin supports T-cell motility and activation. Immunol Rev 256:48-62
Todd, Elizabeth M; Deady, Lauren E; Morley, Sharon Celeste (2013) Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin. Eur J Immunol 43:1735-44
Winston, Julia B; Schulkey, Claire E; Chen, Iuan-Bor D et al. (2012) Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation. Circ Cardiovasc Genet 5:293-300
Kaur, Kuljeet; Parra, Sergio; Chen, Rong et al. (2012) Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol 385:443-53

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