The University of Michigan Child Health Research Career Development Award (CHRCDA) program entitled "Advancing Child Health through Cellular and Molecular Biology" is designed to support the research career development of promising young pediatric investigators. The focus of this research program is to foster the research programs of young pediatric investigators whose work is designed to advance our understanding of biological systems and disease processes in child health. The program places particular emphasis on three fundamental areas of research inquiry-cellular and molecular biology, genetics and developmental biology, cellular growth, host defense and immunology, and more recently, bioimaging and biomarker disease discovery and pathogenesis. The specific goals of the program are: (a) to provide junior pediatric physician- scientists with the infrastructure, technologies and opportunity to study basic mechanisms and the pathogenesis of diseases that impact children's health;(b) to provide a unique opportunity for junior pediatric physician-scientists to acquire new, innovative and state-of the art scientific expertise in cellulr and molecular biology and the associated bioinformatics/systems biology approaches;(c) to provide junior pediatric physician-scientists with the research understanding and bench research skills required to establish a successful independent research program;and (d) to recruit talented junior pediatricians with particular efforts directed towards minority and woman candidates to careers in academic pediatrics. To achieve these goals, we have assembled senior faculty from diverse biomedical research fields to serve as research mentors for our trainees. The program has established an advisory committee to oversee the selection of CHRCDA scholars and the program has put in place two recruitment officers to assist in the identification and recruitment of minority and women candidates. The CHRCDA scholars participate in intensive training programs in cellular and molecular biology as well as a mentorship program designed to ensure their continued research development. This program has contributed to the training of more than 40 pediatric-investigators who have gone on to establish successful research programs designed to improve our understanding of childhood disease as well as develop new therapeutic approaches to treat childhood disease.

Public Health Relevance

The University of Michigan Children's Health Research Center program attracts accomplished pediatricians and subspecialty pediatric providers to train under the guidance of accomplished biomedical scientists. These pediatricians gain understanding and experience in scientific methods, tools and technologies that they then apply to study diseases that afflict children and young adults. The program has been highly successful in attracting accomplished physicians into careers in academic pediatrics.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD028820-22
Application #
8601717
Study Section
Special Emphasis Panel (ZHD1-DSR-N (53))
Program Officer
Winer, Karen
Project Start
2002-02-15
Project End
2017-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
22
Fiscal Year
2014
Total Cost
$428,863
Indirect Cost
$31,768
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Singer, Kanakadurga; DelProposto, Jennifer; Morris, David Lee et al. (2014) Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells. Mol Metab 3:664-75
Singer, Kanakadurga; Eng, Donna S; Lumeng, Carey N et al. (2014) The relationship between body fat mass percentiles and inflammation in children. Obesity (Silver Spring) 22:1332-6
Gregg, Brigid; Elghazi, Lynda; Alejandro, Emilyn U et al. (2014) Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors. Diabetologia 57:2566-75
Weyand, Angela C; Shavit, Jordan A (2014) Zebrafish as a model system for the study of hemostasis and thrombosis. Curr Opin Hematol 21:418-22
Cho, Kae Won; Morris, David L; DelProposto, Jennifer L et al. (2014) An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation. Cell Rep 9:605-17
Hazle, Matthew A; Gajarski, Robert J; Yu, Sunkyung et al. (2013) Fluid overload in infants following congenital heart surgery. Pediatr Crit Care Med 14:44-9
Byersdorfer, Craig A; Tkachev, Victor; Opipari, Anthony W et al. (2013) Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood 122:3230-7
Desch, Karl C; Ozel, Ayse B; Siemieniak, David et al. (2013) Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A 110:588-93
Quinonez, Shane C; Leber, Steven M; Martin, Donna M et al. (2013) Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency. Pediatr Neurol 48:67-72
Adler, Jeremy; Punglia, Darashana R; Dillman, Jonathan R et al. (2012) Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn's disease. Inflamm Bowel Dis 18:849-56

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