This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research trainmg including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators;2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with exceljence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet pur training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physian-scholars as they begin highly productive academic careers in pediatric science.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD028827-19
Application #
7752795
Study Section
Special Emphasis Panel (ZHD1-DSR-T (16))
Program Officer
Winer, Karen
Project Start
2002-02-20
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
19
Fiscal Year
2010
Total Cost
$240,305
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Alder, Matthew N; Opoka, Amy M; Lahni, Patrick et al. (2017) Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock. Crit Care Med 45:e426-e432
Ritter, Alyssa; Atzinger, Carrie; Hays, Brandon et al. (2017) Natural history of aortic root dilation through young adulthood in a hypermobile Ehlers-Danlos syndrome cohort. Am J Med Genet A 173:1467-1472
Badawy, Sherif M; Black, Vandy; Meier, Emily R et al. (2017) Early career mentoring through the American Society of Pediatric Hematology/Oncology: Lessons learned from a pilot program. Pediatr Blood Cancer 64:
Rosen, Michael J; Karns, Rebekah; Vallance, Jefferson E et al. (2017) Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Gastroenterology 152:1345-1357.e7
Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C et al. (2017) The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood 130:1336-1346
Gloude, Nicholas J; Khandelwal, Pooja; Luebbering, Nathan et al. (2017) Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD. Blood 130:1259-1266
El-Bietar, J; Nelson, A; Wallace, G et al. (2016) RSV infection without ribavirin treatment in pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant 51:1382-1384
Jodele, Sonata; Dandoy, Christopher E; Myers, Kasiani C et al. (2016) New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Transfus Apher Sci 54:181-90
Pate, A; Rotz, S; Warren, M et al. (2016) Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation. Bone Marrow Transplant 51:310-2
Myers, K C; Howell, J C; Wallace, G et al. (2016) Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults. Bone Marrow Transplant 51:980-4

Showing the most recent 10 out of 95 publications