This application is a competitive renewal for our Child Health Research Career Development Award (CHRCDA), which has established a unique nexus of excellence for the enhancement of basic, translational, and clinical research training and career development in pediatrics. This long-standing career development program, designed to guide junior faculty during their transition to independent research careers in pediatric medicine, is now in its twentieth year at Cincinnati Children's Hospital Medical Center (CCHMC), with this being our fourth renewal application. Our CHRCDA has supported 42 CHRCDA Scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our Scholars have published over 1,400 peer-reviewed publications and been awarded over $81 million in direct grant funding and 41 NIH R01 grants. The CCHMC CHRCDA Program synergizes with our other innovative, established programs for research training including the Procter Scholar Program and the NIH Clinical and Translational Science Award (CTSA), especially its KL2 component, as well as with an array of NIH-funded research programs. In contrast to these programs, our CHRCDA Program specifically targets pediatricians and has the advantage of offering training and career development across a wide array of disciplines and specialties in basic, translational, and clinical research. Our CHRCDA Program identifies and recruits promising young pediatric faculty. A CCHMC physician scientist typically completes a 3- to 5-year track in research training and career development and is provided mentorship from 1 or more senior faculty. For our CHRCDA Scholars, generally 2 years of this track are funded by the CHRCDA, and the provided scientific guidance by our exceptional and highly committed CHRCDA primary faculty mentors is complemented by additional curricula, seminars, and resources. Specific aspects of the Program are customized based on the individual needs of the Scholar, especially their prior experiences and current competencies. The present CCHMC CHRCDA Program, under direction of the Principal Investigator, Program Director, and its Administrative Core, has drawn together established investigators with excellence in pediatric science and mentoring at CCHMC and the University of Cincinnati College of Medicine (UCCOM) to serve as primary mentors for the pediatric physician scientists during their transition to independence. The Program's Administrative Core identifies candidates, monitors the overall career development of our Scholars, and provides support for recruitment efforts at local and national levels, prioritizing Scholar recruitment from underrepresented groups. The CCHMC CHRCDA Program's combination of individual mentorship, advanced training, and research-conducive environment and resources (e.g. CCHMC Research Cores) is a needed and successful strategy to enhance the research productivity and independence of our pediatric physician scientists as they begin their academic careers in pediatric medicine.

Public Health Relevance

The CCHMC CHRCDA Program seeks to enhance the professional development, research capability, and interest of young pediatric physician scientists who seek a full-time career in research with a major interest in pediatrics. The objective is to equip these young faculty who are just starting their careers in academic pediatrics with the skills necessary to succeed in meaningful, independent scientific careers in academic medicine. We aim to train the next generation of leaders in academic pediatrics.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
4K12HD028827-25
Application #
8976232
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Lee, Karen
Project Start
2002-02-20
Project End
2016-11-30
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
25
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Barnes-Davis, Maria E; Merhar, Stephanie L; Holland, Scott K et al. (2018) Extremely preterm children exhibit increased interhemispheric connectivity for language: findings from fMRI-constrained MEG analysis. Dev Sci 21:e12669
Schlaudecker, Elizabeth P; Ambroggio, Lilliam; McNeal, Monica M et al. (2018) Declining responsiveness to influenza vaccination with progression of human pregnancy. Vaccine 36:4734-4741
Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C et al. (2017) The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood 130:1336-1346
Pfeiffer, T M; Rotz, S J; Ryan, T D et al. (2017) Pericardial effusion requiring surgical intervention after stem cell transplantation: a case series. Bone Marrow Transplant 52:630-633
Gloude, Nicholas J; Khandelwal, Pooja; Luebbering, Nathan et al. (2017) Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD. Blood 130:1259-1266
Badawy, Sherif M; Black, Vandy; Meier, Emily R et al. (2017) Early career mentoring through the American Society of Pediatric Hematology/Oncology: Lessons learned from a pilot program. Pediatr Blood Cancer 64:
Alder, Matthew N; Opoka, Amy M; Lahni, Patrick et al. (2017) Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock. Crit Care Med 45:e426-e432
Ritter, Alyssa; Atzinger, Carrie; Hays, Brandon et al. (2017) Natural history of aortic root dilation through young adulthood in a hypermobile Ehlers-Danlos syndrome cohort. Am J Med Genet A 173:1467-1472
Minar, Phillip; Jackson, Kimberly; Tsai, Yi-Ting et al. (2017) Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn's Disease. Inflamm Bowel Dis 24:198-208
Rosen, Michael J; Karns, Rebekah; Vallance, Jefferson E et al. (2017) Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Gastroenterology 152:1345-1357.e7

Showing the most recent 10 out of 100 publications