Abstract

This application seeks renewal of a highly successful CHRCDA, which supports the transitional training of pediatric scientists studying molecular and cellular aspects of childhood disease in the Department of Pediatrics, University of Washington School of Medicine. The objectives of this program are to identify, encourage, and support promising young pediatricians by facilitating their acquisition of the education, skills and experience required to initiate independent investigative careers. The new investigators and senior faculty advisors have laboratories at the University and its affiliated institutions: the Children's Hospital &Regional Medical Center and Fred Hutchinson Cancer Research Center, where the Department of Pediatrics has established clinical and research programs. The Program Director and members of the Internal Advisory Committee are available to advise at informal seminars and through an annual progress report and on a day-to-day basis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043376-10
Application #
8197166
Study Section
Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
Project Start
2003-04-11
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2013-11-30
Support Year
10
Fiscal Year
2012
Total Cost
$354,916
Indirect Cost
$49,009

  Institution

Name
University of Washington
Department
Pediatrics
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Cheung, Ronald S; Castella, Maria; Abeyta, Antonio et al. (2017) Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex. Cell Rep 19:2432-2440
Jackson, Shaun W; Scharping, Nicole E; Kolhatkar, Nikita S et al. (2014) Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol 192:4525-32
Traudt, Christopher M; McPherson, Ron J; Studholme, Colin et al. (2014) Systemic glycerol decreases neonatal rabbit brain and cerebellar growth independent of intraventricular hemorrhage. Pediatr Res 75:389-94
Ho, Phoenix A; Alonzo, Todd A; Gerbing, Robert B et al. (2014) The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: report from the Children's Oncology Group. Pediatr Blood Cancer 61:81-8
Diede, Scott J; Yao, Zizhen; Keyes, C Chip et al. (2013) Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. Epigenetics 8:1254-60
Bermejo, Daniela A; Jackson, Shaun W; Gorosito-Serran, Melisa et al. (2013) Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors ROR?t and Ahr that leads to IL-17 production by activated B cells. Nat Immunol 14:514-22
MacQuarrie, Kyle L; Yao, Zizhen; Fong, Abraham P et al. (2013) Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. Mol Cell Biol 33:773-84
Mitchell, Anna L; Judis, LuAnn M; Schwarze, Ulrike et al. (2012) Characterization of tissue-specific and developmentally regulated alternative splicing of exon 64 in the COL5A1 gene. Connect Tissue Res 53:267-76
Bachmann-Gagescu, Ruxandra; Ishak, Gisele E; Dempsey, Jennifer C et al. (2012) Genotype-phenotype correlation in CC2D2A-related Joubert syndrome reveals an association with ventriculomegaly and seizures. J Med Genet 49:126-37
Yamaguchi, Ikuyo; Tchao, Bie Nga; Burger, Megan L et al. (2012) Vascular endothelial cadherin modulates renal interstitial fibrosis. Nephron Exp Nephrol 120:e20-31

Showing the most recent 10 out of 40 publications