This is a new proposal to initiate a program to train young pediatricians for careers in investigative research at the University of Chicago. The proposal builds on the long-standing reputation of the Department of Pediatrics in preparing medical students for research careers and the tradition of the Pritzker School of Medicine in emphasizing the importance of basic science in clinical practice. There is strong Institutional commitment to recruitment, salaries, equipment, core laboratories and administration. In selecting the CHRCDA Scholars we will rely both on our own pool of MD/PhD graduates and our successful programs to recruit underrepresented minorities and women into research. We have chosen a group of 26 potential mentors and senior collaborators who reflect international research excellence in the areas of human genetics, growth and development and the cellular and molecular mechanisms of pediatric disease. CHRCDA Scholars will be Instructors or Assistant Professors in the Department of Pediatrics and will spend sufficient time in their chosen mentor's laboratory to acquire the technical skills and academic depth of knowledge to enable them to develop a competitive, independent research program. They will also have the opportunity to take advanced didactic graduate courses in their chosen area of research and to receive instruction in grant writing and the responsible conduct of research. The University and Department are committed to providing core facilities and matching funds to promote career development of the CHRCDA Scholars.
The specific aims of the program are to: 1. Ensure that the Scholars receive the most up-to-date, broad-based training available. 2. Provide a nurturing environment for the Scholars both in terms of personal and intellectual development and in terms of the availability of core support for their research project. 3. Make available to the Scholars the most modern techniques possible. 4. Instill a sense of enthusiasm for knowledge that will sustain the Scholars when time conflicts make hard choices a necessity and convince them that they can combine superb care of children with fundamental research. 5. Convince the Scholars that research can make a very real difference in the long term to healthcare care of children and show them how this can be achieved.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043387-04
Application #
6994418
Study Section
Special Emphasis Panel (ZHD1-DSR-A (19))
Program Officer
Winer, Karen
Project Start
2003-04-11
Project End
2007-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
4
Fiscal Year
2006
Total Cost
$413,923
Indirect Cost
Name
University of Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Wolfson, Rachel K; Chiang, Eddie T; Garcia, Joe G N (2011) HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res 81:189-97
Seow, Chun Y; Solway, Julian (2011) Mechanical and structural plasticity. Compr Physiol 1:283-93
Marcuccilli, Charles J; Tryba, Andrew K; van Drongelen, Wim et al. (2010) Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol 27:387-97
Dowell, M L; Lavoie, T L; Lakser, O J et al. (2010) MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J 36:630-7
Montgomery, Christopher P; Boyle-Vavra, Susan; Daum, Robert S (2009) The arginine catabolic mobile element is not associated with enhanced virulence in experimental invasive disease caused by the community-associated methicillin-resistant Staphylococcus aureus USA300 genetic background. Infect Immun 77:2650-6
Montgomery, Christopher P; Daum, Robert S (2009) Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: a role for panton-valentine leukocidin? Infect Immun 77:2159-67
Montgomery, Christopher P; Boyle-Vavra, Susan; Adem, Patricia V et al. (2008) Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis 198:561-70
Lakser, O J; Dowell, M L; Hoyte, F L et al. (2008) Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J 32:1224-30
Chen, Bohao; Liu, Gustine; Shardonofsky, Felix et al. (2006) Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol 101:249-55
Dowell, M L; Lakser, O J; Gerthoffer, W T et al. (2005) Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol 98:489-97

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