As a major part of the overall goal to improve the health of children, the Department of Pediatrics of the University of Alabama School of Medicine (UASOM) has proposed a comprehensive plan for the mentored training of outstanding young pediatric physician scientists in translational biomedical research. This training program will be implemented through the Child Health Research Center (CHRC) and will take optimal advantage of the existing integrated basic and translational research capacity of the UASOM. The CHRC will focus its training in four key areas of research in child health: (1) infectious diseases and immunology, (2) diseases associated with lung injury, (3) neurodevelopmental diseases, and (4) genetic diseases. These areas have been selected because of their importance in child health and because the resources available within the UASOM will foster an outstanding mentored training experience in these areas of biomedical research. The proposed CHRC will build on our previous success in the training of pediatric physician scientists by refining the organization of our training program, including implementation of formal curriculum in translational research. In addition, the CHRC has incorporated a series of internal and external mechanisms of evaluation to insure all facets of the CHRC, extending from the leadership to the CHRC scholar, meet the objectives of the projected training program. Our overall goal is to institute and maintain an optimized mentored training program for the development of pediatric physician scientists who will be expected to transition into academic careers as independent investigators in translational biomedical research in child health. The significance to public health derives from the relevance of the four key areas of research to child health. In addition, we anticipate that well-trained pediatric physician scientists will have long, productive academic careers with many opportunities to disseminate scientific information and impact the future generations of pediatricians.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043397-10
Application #
8214531
Study Section
Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
Project Start
2003-04-11
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2013-11-30
Support Year
10
Fiscal Year
2012
Total Cost
$359,807
Indirect Cost
$27,285
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Hanks, Lynae J; Gutiérrez, Orlando M; Ashraf, Ambika P et al. (2015) Bone Mineral Content as a Driver of Energy Expenditure in Prepubertal and Early Pubertal Boys. J Pediatr 166:1397-403
Ashraf, Ambika P; Alvarez, Jessica A; Dudenbostel, Tanja et al. (2014) Associations between vascular health indices and serum total, free and bioavailable 25-hydroxyvitamin D in adolescents. PLoS One 9:e114689
Ashraf, Ambika P; Huisingh, Carrie; Alvarez, Jessica A et al. (2014) Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J Clin Endocrinol Metab 99:178-83
Hanks, Lynae J; Ashraf, Ambika P; Gower, Barbara A et al. (2013) Subclinical Indication of Linkage Between Markers of Skeletal and Cardiovascular Properties. Bone Res 1:
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Bhaumik, Suniti; Giffon, Thierry; Bolinger, Derek et al. (2013) Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants. J Immunol 190:2603-13
Ashraf, Ambika P; Alvarez, Jessica; Huisingh, Carrie et al. (2013) Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents. Br J Med Med Res 3:1050-1061
Hanks, L J; Casazza, K; Ashraf, A et al. (2012) Calcium homeostasis may influence resting energy expenditure with effects most apparent in early pubertal girls. Acta Paediatr 101:e363-8
Ashraf, Ambika P; Fisher, Gordon; Alvarez, Jessica et al. (2012) Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults. J Nutr Metab 2012:475975
Benaderet, Amanda D; Burton, Amy M; Clifton-Bligh, Roderick et al. (2011) Primary hyperparathyroidism with low intact PTH levels in a 14-year-old girl. J Clin Endocrinol Metab 96:2325-9

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