As a major part of the overall goal to improve the health of children, the Department of Pediatrics of the University of Alabama School of Medicine (UASOM) has proposed a comprehensive plan for the mentored training of outstanding young pediatric physician scientists in translational biomedical research. This training program will be implemented through the Child Health Research Center (CHRC) and will take optimal advantage of the existing integrated basic and translational research capacity of the UASOM. The CHRC will focus its training in four key areas of research in child health: (1) infectious diseases and immunology, (2) diseases associated with lung injury, (3) neurodevelopmental diseases, and (4) genetic diseases. These areas have been selected because of their importance in child health and because the resources available within the UASOM will foster an outstanding mentored training experience in these areas of biomedical research. The proposed CHRC will build on our previous success in the training of pediatric physician scientists by refining the organization of our training program, including implementation of formal curriculum in translational research. In addition, the CHRC has incorporated a series of internal and external mechanisms of evaluation to insure all facets of the CHRC, extending from the leadership to the CHRC scholar, meet the objectives of the projected training program. Our overall goal is to institute and maintain an optimized mentored training program for the development of pediatric physician scientists who will be expected to transition into academic careers as independent investigators in translational biomedical research in child health. The significance to public health derives from the relevance of the four key areas of research to child health. In addition, we anticipate that well-trained pediatric physician scientists will have long, productive academic careers with many opportunities to disseminate scientific information and impact the future generations of pediatricians.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Schools of Medicine
United States
Zip Code
Ashraf, Ambika P; Huisingh, Carrie; Alvarez, Jessica A et al. (2014) Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J Clin Endocrinol Metab 99:178-83
Bhaumik, Suniti; Giffon, Thierry; Bolinger, Derek et al. (2013) Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants. J Immunol 190:2603-13
Chewning, Joseph H; Zhang, Weiwei; Randolph, David A et al. (2013) Allogeneic Th1 cells home to host bone marrow and spleen and mediate IFNýý-dependent aplasia. Biol Blood Marrow Transplant 19:876-87
Ashraf, Ambika P; Alvarez, Jessica A; Gower, Barbara A et al. (2011) Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity (Silver Spring) 19:2214-21
Benaderet, Amanda D; Burton, Amy M; Clifton-Bligh, Roderick et al. (2011) Primary hyperparathyroidism with low intact PTH levels in a 14-year-old girl. J Clin Endocrinol Metab 96:2325-9
Gardner, James; Ashraf, Ambika; You, Zhiying et al. (2011) Changes in plasma FGF23 in growth hormone deficient children during rhGH therapy. J Pediatr Endocrinol Metab 24:645-50
Maheshwari, Akhil; Kelly, David R; Nicola, Teodora et al. (2011) TGF-ýý2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140:242-53
Ashraf, Ambika P; Beukelman, Timothy; Pruneta-Deloche, Valerie et al. (2011) Type 1 hyperlipoproteinemia and recurrent acute pancreatitis due to lipoprotein lipase antibody in a young girl with Sjogren's syndrome. J Clin Endocrinol Metab 96:3302-7
Kurundkar, Ashish R; Killingsworth, Cheryl R; McIlwain, R Britt et al. (2010) Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet. Pediatr Res 68:128-33
McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R et al. (2010) Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine. Lab Invest 90:128-39

Showing the most recent 10 out of 23 publications