The Duke Department of Pediatrics'training program is based on developing pediatric Junior Faculty into physician-scientists who are skilled in cutting-edge methods of laboratory research and who will pursue independent academic careers investigating important issues related to childhood diseases. Our program is based on our pool of outstanding candidates, a strong curriculum of didactic courses, experienced mentors who perform state-of-the-art research, and an excellent research environment. Our commitment to develop future academic pediatricians is evidenced by the academic success of our Junior Faculty. Our Principal Investigator is Dr. Joseph St. Geme, III, Chairman of the Department who is assisted by Dr. Page Anderson, Program Director, Dr. Delbert Wigfall, Minority Recruitment Advisor, and an Internal and External Advisory Committee. Four young scholars will be supported each year. They will be drawn primarily from our fellows and Junior Faculty. Recruitment of underrepresented minorities is a focus of the program. Our faculty, which includes many mentors from other Departments; have strong track records in research, funding, and mentoring . Our research training centers are in the areas of Developmental Biology, Cell Biology and Cell Signaling, Microbiology and Immunology, and Genetics, Genomics, and Proteomics. Didactic courses, including a multi-lecture course on writing, will complement the laboratory research experiences, enabling the trainees to write and submit grant applications to support their career. The trainees will be required to take a five lecture course in Responsible Conduct of Research. The young Scholars will have access to all the research resources of the NCI-funded Comprehensive Cancer Center, the shared facilities at Duke University, the Institute for Genome Sciences and Policy, and the Center for Human Genetics.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043494-10
Application #
8197163
Study Section
Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
Project Start
2003-04-11
Project End
2012-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
10
Fiscal Year
2012
Total Cost
$372,276
Indirect Cost
$28,103
Name
Duke University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Wang, Xiaoming; Bey, Alexandra L; Chung, Leeyup et al. (2014) Therapeutic approaches for shankopathies. Dev Neurobiol 74:123-35
Jiang, Yong-Hui; Ehlers, Michael D (2013) Modeling autism by SHANK gene mutations in mice. Neuron 78:8-27
Chinn, I K; Milner, J D; Scheinberg, P et al. (2013) Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly. Clin Exp Immunol 173:140-9
Belyea, Brian C; Naini, Sarasija; Bentley, Rex C et al. (2011) Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Clin Cancer Res 17:7324-36
Chinn, Ivan K; Markert, M Louise (2011) Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly. J Allergy Clin Immunol 127:1351-5
MacIver, Nancie J; Blagih, Julianna; Saucillo, Donte C et al. (2011) The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol 187:4187-98
Chinn, Ivan K; Olson, John A; Skinner, Michael A et al. (2010) Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation. J Allergy Clin Immunol 126:814-820.e8
Naini, Sarasija; Etheridge, Katherine T; Adam, Stacey J et al. (2008) Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. Cancer Res 68:9583-8
Linardic, Corinne M (2008) PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett 270:10-8
Idriss, Salim F; Bell, Jamie A (2008) Cardiac repolarization instability during normal postnatal development. J Electrocardiol 41:474-9

Showing the most recent 10 out of 16 publications