The Department of Obstetrics, Gynecology, and Reproductive Sciences proposes to continue the Yale Women's Reproductive Health Research (WRHR) Career Development Center with the goal of selecting outstanding novice or more experienced physician scientists for advanced training in basic, translational, or clinical science under the guidance of skilled scientific mentors. The Principal Investigator/Program Director (PD/PI) and Research Director (RD) will monitor the Scholars'academic progress toward research independence. We identify prospective scholars from our residents, subspecialty fellows, and junior faculty, as well as national networking by the PD/PI and RD and advertisements in professional journals, letters to program directors and Chairs and postings at national meetings. Our selection committee chooses WRHR Scholars who exhibit exceptional promise and commitment to a career in women's health research. The PD/PI, RD, and Advisory Committee are directly involved in the training, evaluation and academic development of each WRHR Scholar. Mentors are experienced in career development and are outstanding scientists in fields related to Women's Reproductive Health. Core training in basic lab techniques and molecular biology, along with a didactic program, are required for all WRHR Scholars and include instruction in the responsible and ethical conduct of research. There are three WRHR Scholars in the Department at any given time, with each Scholar assigned departmental laboratory space with access to shared teaching and training cores. In addition to having 75% time directly covered by the Center, in order to pursue career development. Scholars will receive research support for 2-5 years to underwrite costs while they obtain preliminary data and develop grant applications. Scholars enter the Department of Ob/Gyn as Assistant Professors, with appropriate office and support staff. Clinical duties and responsibilities relate directly to research interests. Career development will span two to five years, depending on the individual Scholar's initial level of experience and particular training goals as a Scholar. The Yale WRHR Center aims to foster Scholars'development into established, independent investigators. Yale seeks to retain as faculty Scholars who successfully complete the individualized training program at Yale and who have made significant progress toward independent funding.

Public Health Relevance

The Yale WRHR Center will train Obstetrician /Gynecologists to develop into independent physician- scientists with research expertise in women's reproductive health, thereby addressing a national shortage of scientists with the appropriate clinical skills necessary to foster translational research discoveries required to advance women's health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD047018-09
Application #
8323512
Study Section
Special Emphasis Panel (ZHD1-DSR-L (14))
Program Officer
Parrott, Estella C
Project Start
2004-05-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$475,200
Indirect Cost
$35,200
Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mak, Winifred; Xia, Jing; Cheng, Ee-Chun et al. (2018) A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. Cell Biosci 8:54
Li, Fei; Alderman 3rd, Myles H; Tal, Aya et al. (2018) Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 36:881-890
Collins, Stephen C; Xu, Xiao; Mak, Winifred (2017) Cost-effectiveness of preimplantation genetic screening for women older than 37 undergoing in vitro fertilization. J Assist Reprod Genet 34:1515-1522
Mak, Winifred; Kondapalli, Laxmi A; Celia, Gerard et al. (2016) Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF. Hum Reprod 31:789-94
Grimstad, F W; Nangia, Ajay K; Luke, B et al. (2016) Use of ICSI in IVF cycles in women with tubal ligation does not improve pregnancy or live birth rates. Hum Reprod 31:2750-2755
Whicker, Margaret E; Lin, Z Ping; Hanna, Ruth et al. (2016) MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. BMC Cancer 16:550
Ishiguro, Kimiko; Zhu, Yong-Lian; Lin, Z Ping et al. (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2:117-124
Ratner, Elena S; Zhu, Yong-Lian; Penketh, Philip G et al. (2016) Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair. Br J Cancer 114:777-86
Mak, Winifred; Fang, Caodi; Holden, Tobias et al. (2016) An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod 94:134
Flores, Valerie A; Taylor, Hugh S (2015) The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk. Endocrinol Metab Clin North Am 44:587-602

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