This is a renewal application for a mentored training program for pediatric subspecialty faculty interested in basic research careers. The program offers a 1- to 3-year experience dedicated to training in cell and molecular biology research that is relevant to child health for 4 Scholars per year and is designed to serve as a launch for a career as a NIH R01-funded pediatric physician scientist. The mentoring faculty includes 21 outstanding basic researchers who have a distinguished record of research contributions and mentoring. The philosophical emphasis of this mentoring experience is fundamentals of the scientific method combined with the highest standard of excellence for rigor and integrity. Each of the Scholars is expected to carry out a challenging research project in the laboratory of one of the faculty mentors leading to publications as well as an application for their own K08, K99/R00 or R01 grant. The Department of Pediatrics at Pitt has one of the fastest growing pediatric research programs in the country and is based on a new Children's Hospital of Pittsburgh of UPMC campus with the new 300,000-square-foot CHP Rangos Pediatric Research Building. Follow-up from the initial term of the CHRC program at Pitt (1992-1997) shows that 4 of the 8 Scholars are now R01- funded professors and 3 of these are division chiefs. Two other graduates are full professors involved in NIH-funded research as co-investigators. Of the 6 scholars that have graduated from the second term of the program (2007-present), 5 have already competed successfully for NIH (or equivalent) funding as a PI, including one R01, 3 K awards and 1 RWJ Foundation Minority Mentored Scholar Award. Over the last 10 years the Department has used its own resources to support a similar experience for 10 additional junior faculty (CHP Scholars), all of whom have competed successfully for, or moved forward towards, independent funding (3 R01, 1 K99/R00, 4 K08/K23, 1 R21 and 1 Gates Foundation). Based on these characteristics and results, we believe that this program provides a powerful team of mentors and intellectually-rich environment that will inspire junior faculty in pediatric subspecialties and provide them with the background to become the next generation of successful child health researchers.

Public Health Relevance

All of the training experiences in this program involve research on mechanisms of human diseases including neurodevelopmental disorders, inborn errors of metabolism, congenital anomalies, infections, shock, cancer, cystic fibrosis, hypertensive kidney disease, transplant tolerance, immune disorders, chronic obstructive pulmonary disease, diabetes and disorders of the premature newborn.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-N (53))
Program Officer
Winer, Karen
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
O'Donnell, Brighid M; Mackie, Timothy D; Brodsky, Jeffrey L (2017) Linking chanelopathies with endoplasmic reticulum associated degradation. Channels (Austin) 11:499-501
Hughan, Kara S; Wendell, Stacy Gelhaus; Delmastro-Greenwood, Meghan et al. (2017) Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. Hypertension :
Tsiarli, M A; Rudine, A; Kendall, N et al. (2017) Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior. Transl Psychiatry 7:e1153
Khan, Zahida; Strom, Stephen C (2017) Hepatocyte Transplantation in Special Populations: Clinical Use in Children. Methods Mol Biol 1506:3-16
O'Donnell, Brighid M; Mackie, Timothy D; Subramanya, Arohan R et al. (2017) Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome. J Biol Chem 292:12813-12827
Khan, Zahida; Orr, Anne; Michalopoulos, George K et al. (2017) Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatr Dev Pathol 20:16-27
Frahm, Krystle A; Waldman, Jacob K; Luthra, Soumya et al. (2017) A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol :
Abu-El-Haija, Maisam; Kumar, Soma; Quiros, J Antonio et al. (2017) The Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report from the NASPGHAN Pancreas Committee. J Pediatr Gastroenterol Nutr :
Khan, Zahida; Yokota, Shinichiro; Ono, Yoshihiro et al. (2017) Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of ?-1 Antitrypsin Deficiency. Gene Expr 17:115-127
Khan, Zahida; Venkat, Veena L; Soltys, Kyle A et al. (2017) A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency. Pediatr Dev Pathol 20:176-181

Showing the most recent 10 out of 84 publications