A solid grounding in basic research skills is essential for investigators seeking to understand the scientific basis of childhood disease. The long-term goal of this application for a Child Health ResearchCareer Development Award (CHRCDA) is to strengthen the cadre of clinician-scientists at our institution who serve as a critical, bi-directional bridge between the excellent basic research and clinical activities in our academic medical center. We will accomplish this by mentoring and further educating outstanding candidates, helping them become knowledgeable regarding basic science, its relationship to clinical practice, and practical skills important to being physician-scientists such as paper writing, grant preparation and time management. We will accomplish this with a program of mentorship, utilizing successful, experienced investigators who have a track record of nurturing the development of successful investigators. As detailed in the application, our Department has an established track record in preparing physician-scientists for independent research careers. We will offer carefully selected CHRCDA Scholars a closely supervised program that combines protected time, resources and didactic training, along with the mentored research experience. A strong research-intensive environment is described that will offer knowledge, experience and support in facilitating the growth and development of academic pediatricians who will serve as leaders in translational investigation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD052902-04
Application #
7535172
Study Section
Special Emphasis Panel (ZHD1-DSR-T (27))
Program Officer
Winer, Karen
Project Start
2006-03-01
Project End
2010-11-30
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
4
Fiscal Year
2009
Total Cost
$360,762
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
074438755
City
Chicago
State
IL
Country
United States
Zip Code
60611
Cohran, Valeria; Managlia, Elizabeth; Bradford, Emily M et al. (2016) Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection. Am J Pathol 186:1837-1846
Lee, Keng Jin; Berkelhamer, Sara K; Kim, Gina A et al. (2014) Disrupted pulmonary artery cyclic guanosine monophosphate signaling in mice with hyperoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol 50:369-78
Berkelhamer, Sara K; Kim, Gina A; Radder, Josiah E et al. (2013) Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung. Free Radic Biol Med 61:51-60
Rossi, Janet L; Ralay Ranaivo, Hantamalala; Patel, Fatima et al. (2011) Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase. J Neurosci Res 89:852-61
Venkatesan, Charu; Chrzaszcz, MaryAnn; Choi, Nicole et al. (2010) Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation 7:32
Chrzaszcz, MaryAnn; Venkatesan, Charu; Dragisic, Tina et al. (2010) Minozac treatment prevents increased seizure susceptibility in a mouse ""two-hit"" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures. J Neurotrauma 27:1283-95
Gupta, Ruchi S; Weiss, Kevin B (2009) The 2007 National Asthma Education and Prevention Program asthma guidelines: accelerating their implementation and facilitating their impact on children with asthma. Pediatrics 123 Suppl 3:S193-8
Chen, Bernadette; Lakshminrusimha, Satyan; Czech, Lyubov et al. (2009) Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep. Pediatr Res 66:682-7
Muller, William J; Dong, Lichun; Vilalta, Adrian et al. (2009) Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection. J Gen Virol 90:1153-63
Gupta, Ruchi S; Zhang, Xingyou; Sharp, Lisa K et al. (2009) The protective effect of community factors on childhood asthma. J Allergy Clin Immunol 123:1297-304.e2

Showing the most recent 10 out of 13 publications