This application requests funding to establish a Child Health Research Career Development Award (CHRCDA) center within the Department of Pediatrics at Children's Hospital Los Angeles/Keck School of Medicine, University of Southern California (USC). The objective of our program is to support the research career development of newly appointed pediatric faculty members. One or two CHRCDA scholars will be selected each year from a pool of candidates recruited from internal training programs or following national searches. Measures to attract women and minority applicants will be incorporated with each recruitment. The Chair of Pediatrics will serve as principal investigator and the PI, in concert with the Program Director, internal Advisory Committee, and recruitment officer, will administer the program. Our CHRCDA center has 30 USC senior faculty research mentors from 9 departments. All CHRCDA scholars will conduct approved research under the guidance of these faculty mentors, all of whom have active NIH funded research programs and experience in mentoring junior faculty. CHRCDA candidates will develop their research proposals with advisory committee approved mentors. A review committee chaired by the Program Director and consisting of external scientists and internal Advisory Committee members will evaluate all proposals. The resulting reviews will be provided to the full Advisory Committee who will then recommend scholars to the PI. The Program Director will provide each applicant with the written critiques and will meet with each applicant to discuss the reviews. In addition to research activities, CHRCDA scholars will also participate in a planned curriculum of formal and informal educational instruction to further enhance their research careers, including two formal courses that cover experimental design, ethics and responsible conduct of research, biostatistics, and bioinformatics, as well as in-vitro and in-vivo research techniques. Scholars also will participate in weekly research seminars and journal clubs. The training and productivity of all scholars will be closely monitored by the Advisory Committee and by the CHLA Academic Council. CHRCDA funding will allow CHLA to continue to build upon the success it has achieved in fostering research career development of pediatric investigators.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD052954-04
Application #
7625244
Study Section
Special Emphasis Panel (ZHD1-DSR-T (27))
Program Officer
Winer, Karen
Project Start
2006-06-01
Project End
2011-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
4
Fiscal Year
2009
Total Cost
$374,947
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Kordy, Kattayoun; Romeo, Anna Claudia; Lee, David J et al. (2018) Combination Antibiotics Improves Disease Activity and Alters Microbial Communities in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr 67:e60-e63
Bender, Jeffrey M; Dien Bard, Jennifer (2018) Metagenomics in pediatrics: using a shotgun approach to diagnose infections. Curr Opin Pediatr 30:125-130
Bender, Jeffrey M; Li, Fan; Adisetiyo, Helty et al. (2018) Quantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies. Microbiome 6:155
Detterich, Jon A (2018) Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc 68:173-186
Cheng, Andrew L; Pahlevan, Niema M; Rinderknecht, Derek G et al. (2018) Experimental Investigation of the Effect of Non-Newtonian Behavior of Blood Flow in the Fontan Circulation. Eur J Mech B Fluids 68:184-192
Detterich, Jon A (2017) Myocardial fibrosis: the heart of diastole? Blood 130:104-105
Mongkolrattanothai, Kanokporn; Naccache, Samia N; Bender, Jeffrey M et al. (2017) Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing. J Pediatric Infect Dis Soc 6:393-398
Ha, V L; Luong, A; Li, F et al. (2017) The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation. Leukemia 31:2503-2514
Pannaraj, Pia S; Li, Fan; Cerini, Chiara et al. (2017) Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome. JAMA Pediatr 171:647-654
Khaleel, Maha; Puliyel, Mammen; Shah, Payal et al. (2017) Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol 92:1137-1145

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