Physicians who have completed a residency and perhaps a fellowship are usually superb clinicians, but generally are not well prepared to meet the research requirements of a career in academic medicine. This proposal describes a plan for a Research Career Development Program in men's reproductive health for pediatricians, internists, endocrinologists and/or urologists at the University of Washington. The major goal of this program is to provide the research training to enable young physicians to establish research careers and eventually become independent investigators. The principal training format proposed is a mentored experience with a successful investigator (clinical, translational or basic) for two to five years. During this time, each of the two scholars will devote most of his/he time to research projects, whereby he/she acquires the knowledge and skills to become independent and assume a faculty position. In addition, in the initial years of each scholar's research training, formal coursework will be provided, as appropriate for the scholar's interests. This proposed UW Male Reproductive Health Research Program has twelve mentors with extensive research experience and funding that collectively represent both strong clinical and basic science expertise in subject areas that directly relate to men's reproductive health. This is a multidisciplinary proposal in that the mentors have their primary expertise and appointments in the Departments of Medicine, Urology, Epidemiology, Pharmacology, Physiology and Biophysics and Obstetrics and Gynecology. Each proposed mentor has a record of excellence in research and documented experience in training young investigators. The Departments of Medicine and Urology will diligently recruit outside scholars, and they have a relatively large pool of residents, fellows, and junior faculty eager to compete for the two proposed scholar awards. The Medicine and Urology departments and the School of Medicine at the University of Washington are prepared to make major commitments of resources and funding to support this proposed research center. In many ways, the University of Washington is the ideal location for a career development program in male reproductive health. The University has a wealth of resources and experience in male reproductive research, and can provide many opportunities for scholars to embark on successful research careers, which will serve to foster new therapeutic breakthroughs in issues relevant to male reproductive health.

Public Health Relevance

Physicians who have expertise in research are needed to improve male reproductive health. The major goal of this program is to provide the research training to enable young physicians to establish research careers and eventually become independent investigators in male reproductive health research. Such research will improve the health and welfare of men and their families.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12HD053984-06
Application #
8368468
Study Section
Special Emphasis Panel (ZHD1-DSR-L (54))
Program Officer
Moss, Stuart B
Project Start
2006-09-01
Project End
2017-07-31
Budget Start
2012-08-15
Budget End
2013-07-31
Support Year
6
Fiscal Year
2012
Total Cost
$332,630
Indirect Cost
$34,431
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Surampudi, P; Page, S T; Swerdloff, R S et al. (2014) Single, escalating dose pharmacokinetics, safety and food effects of a new oral androgen dimethandrolone undecanoate in man: a prototype oral male hormonal contraceptive. Andrology 2:579-87
Sathyanarayana, Sheela; Barrett, Emily; Butts, Samantha et al. (2014) Phthalate exposure and reproductive hormone concentrations in pregnancy. Reproduction 147:401-9
Roth, M Y; Nya-Ngatchou, J J S; Lin, K et al. (2013) Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole. J Clin Endocrinol Metab 98:1198-206
Roth, Mara Y; Lin, Kat; Bay, Katrine et al. (2013) Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial. Fertil Steril 99:132-9
Rubinow, Katya B; Wall, Valerie Z; Nelson, Joel et al. (2013) Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. J Biol Chem 288:9957-70
Hoofnagle, Andrew N; Roth, Mara Y (2013) Clinical review: improving the measurement of serum thyroglobulin with mass spectrometry. J Clin Endocrinol Metab 98:1343-52
Roth, M Y; Ilani, N; Wang, C et al. (2013) Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone(ýý) gels. Andrology 1:899-905
Roth, M Y; Page, S T; Lin, K et al. (2011) The effect of gonadotropin withdrawal and stimulation with human chorionic gonadotropin on intratesticular androstenedione and DHEA in normal men. J Clin Endocrinol Metab 96:1175-81
Roth, M Y; Amory, J K (2011) Pharmacologic development of male hormonal contraceptive agents. Clin Pharmacol Ther 89:133-6
Roth, Mara Y; Elmore, Joann G; Yi-Frazier, Joyce P et al. (2011) Self-detection remains a key method of breast cancer detection for U.S. women. J Womens Health (Larchmt) 20:1135-9

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