Physicians who have completed a residency and perhaps a fellowship are usually superb clinicians, but generally are not well prepared to meet the research requirements of a career in academic medicine. This proposal describes a plan for a Research Career Development Program in men's reproductive health for pediatricians, internists, endocrinologists and/or urologists at the University of Washington. The major goal of this program is to provide the research training to enable young physicians to establish research careers and eventually become independent investigators. The principal training format proposed is a mentored experience with a successful investigator (clinical, translational or basic) for two to five years. During this time, each of the two scholars will devote most of his/he time to research projects, whereby he/she acquires the knowledge and skills to become independent and assume a faculty position. In addition, in the initial years of each scholar's research training, formal coursework will be provided, as appropriate for the scholar's interests. This proposed UW Male Reproductive Health Research Program has twelve mentors with extensive research experience and funding that collectively represent both strong clinical and basic science expertise in subject areas that directly relate to men's reproductive health. This is a multidisciplinary proposal in that the mentors have their primary expertise and appointments in the Departments of Medicine, Urology, Epidemiology, Pharmacology, Physiology and Biophysics and Obstetrics and Gynecology. Each proposed mentor has a record of excellence in research and documented experience in training young investigators. The Departments of Medicine and Urology will diligently recruit outside scholars, and they have a relatively large pool of residents, fellows, and junior faculty eager to compete for the two proposed scholar awards. The Medicine and Urology departments and the School of Medicine at the University of Washington are prepared to make major commitments of resources and funding to support this proposed research center. In many ways, the University of Washington is the ideal location for a career development program in male reproductive health. The University has a wealth of resources and experience in male reproductive research, and can provide many opportunities for scholars to embark on successful research careers, which will serve to foster new therapeutic breakthroughs in issues relevant to male reproductive health.

Public Health Relevance

Physicians who have expertise in research are needed to improve male reproductive health. The major goal of this program is to provide the research training to enable young physicians to establish research careers and eventually become independent investigators in male reproductive health research. Such research will improve the health and welfare of men and their families.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHD1-DSR-L (54))
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Moss, Stuart B
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University of Washington
Internal Medicine/Medicine
Schools of Medicine
United States
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Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Rubinow, Katya B; Vaisar, Tomas; Chao, Jing H et al. (2018) Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men. J Clin Lipidol 12:1072-1082
Shnorhavorian, Margarett; Doody, David R; Chen, Vivien W et al. (2018) Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study. Am J Clin Oncol 41:581-587
Rubinow, Katya B; Rubinow, David R (2017) In immune defense: redefining the role of the immune system in chronic disease. Dialogues Clin Neurosci 19:19-26
Rubinow, Katya B; Chao, Jing H; Hagman, Derek et al. (2017) Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men. Am J Physiol Endocrinol Metab 313:E528-E539
Chao, Jing; Rubinow, Katya B; Kratz, Mario et al. (2016) Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. J Clin Endocrinol Metab 101:3724-3731
Thirumalai, Arthi; Cooper, Lori A; Rubinow, Katya B et al. (2016) Stable Intraprostatic Dihydrotestosterone in Healthy Medically Castrate Men Treated With Exogenous Testosterone. J Clin Endocrinol Metab 101:2937-44
Shnorhavorian, Margarett; Harlan, Linda C; Smith, Ashley Wilder et al. (2015) Fertility preservation knowledge, counseling, and actions among adolescent and young adult patients with cancer: A population-based study. Cancer 121:3499-506
Rubinow, K B; Wang, S; den Hartigh, L J et al. (2015) Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis. Andrology 3:787-96
Thirumalai, Arthi; Rubinow, Katya B; Page, Stephanie T (2015) An update on testosterone, HDL and cardiovascular risk in men. Clin Lipidol 10:251-258

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