Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Only relatively recently have emerging molecular principles been systematically applied to the understanding and treatment of diseases of childhood. However, increasing emphasis on revenue generation, decreasing availability of institutional start-up funds for new investigators, and the individual's imperative for repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of molecular and developmental pediatric knowledge. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between molecular and developmental biology and pediatrics. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained junior faculty the opportunity to engage in and understand basic, and translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic molecular principles towards enhancing and developing our understanding of the developmental origins and mechanisms of childhood disease.
The proposed program will train clinically oriented junior faculty to prepare them for and launch them in careers in molecular pediatrics research. This research will be aimed at understanding and treating diseases of childhood.
|Tesini, Brenda L; Wright, Terry W; Malone, Jane E et al. (2017) Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii. Infect Immun 85:|
|Rezaee, Fariba; Harford, Terri J; Linfield, Debra T et al. (2017) cAMP-dependent activation of protein kinase A attenuates respiratory syncytial virus-induced human airway epithelial barrier disruption. PLoS One 12:e0181876|
|Weber, D R; Stark, L J; Ittenbach, R F et al. (2017) Building better bones in childhood: a randomized controlled study to test the efficacy of a dietary intervention program to increase calcium intake. Eur J Clin Nutr 71:788-794|
|Weber, David R; O'Brien, Kimberly O; Schwartz, George J (2017) Evidence of disordered calcium metabolism in adolescent girls with type 1 diabetes: An observational study using a dual-stable calcium isotope technique. Bone 105:184-190|
|Sanders, James O; Qiu, Xing; Lu, Xiang et al. (2017) The Uniform Pattern of Growth and Skeletal Maturation during the Human Adolescent Growth Spurt. Sci Rep 7:16705|
|Koselny, Kristy; Green, Julianne; DiDone, Louis et al. (2016) The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis. Antimicrob Agents Chemother 60:7115-7127|
|Kuzin, Igor I; Kates, Stephen L; Ju, Yawen et al. (2016) Increased numbers of CD23(+) CD21(hi) Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes. Eur J Immunol 46:1752-7|
|Weber, David; Long, Jin; Leonard, Mary B et al. (2016) Development of Novel Methods to Define Deficits in Appendicular Lean Mass Relative to Fat Mass. PLoS One 11:e0164385|
|Koselny, Kristy; Green, Julianne; Favazzo, Lacey et al. (2016) Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase. ACS Infect Dis 2:268-280|
|Weber, David R; Coughlin, Curtis; Brodsky, Jill L et al. (2016) Low bone mineral density is a common finding in patients with homocystinuria. Mol Genet Metab 117:351-4|
Showing the most recent 10 out of 28 publications