This is a new application (RFA-HD-13-011) for support of the Child Health Research Center at Washington University School of Medicine. Pediatric physician-scientists play a vital role in advancing knowledge related to child health. There is a national need to stimulate child health research by enhancing the training of young pediatric physician-scientists. This program supports the mentored career development of young pediatric physician-scientists by optimally utilizing the resources of the Washington University School of Medicine as we have done for the past 16 years. The long term goal of our Center is to develop Scholars in human developmental biology. We shall achieve this goal by applying the recent advances in basic sciences (developmental biology, cell biology, immunology, genomics, etc.) to an understanding of the pathogenesis of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this, we shall combine the established areas of investigative strength of Washington University School of Medicine and the Department of Pediatrics. Our Scholar's Program, now sixteen years old, will ultimately close the gap between basic scientists and pediatric clinicians. We have in place a programmatic structure in which bright, motivated, young pediatric scientists flourish in a protected environment supported by exceptional mentors and an institutional culture and organization which optimizes their emergence as leaders in an evolving area of Pediatrics. Alan L. Schwartz, Ph.D., M.D. will serve as P.I. /P.D. and Robert Heuckeroth, M.D., Ph.D. will serve as Training Director. The Center (via this award and matched funds from Washington University School of Medicine) and its Scholars will continue to utilize our institutionally-funded core facilities for generation of animal models of human disease states via new and evolving state-of-the-art technologies. The long term goals of the Center will be realized as its Scholars contribute to the development of and leadership in human developmental biology during the next two or more decades.
Pediatric physician-scientists play a vital role in advancing knowledge related to child health. There is a national need to stimulate child health research by enhancing the training of young pediatric physician- scientists. This program supports the mentored career development of young pediatric physician-scientists by optimally utilizing the resources of the Washington University School of Medicine as we have done for the past 16 years.
|Halabi, Carmen M; Mecham, Robert P (2018) Elastin purification and solubilization. Methods Cell Biol 143:207-222|
|Mayer, Allyson L; Zhang, Yiming; Feng, Emily H et al. (2018) Enhanced Hepatic PPAR? Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology 159:2110-2126|
|Higgins, Cassandra B; Zhang, Yiming; Mayer, Allyson L et al. (2018) Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR?. JCI Insight 3:|
|Porter, Shaina N; Magee, Jeffrey A (2017) PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia. Exp Hematol 53:43-47|
|Clark, Amy L; Kanekura, Kohsuke; Lavagnino, Zeno et al. (2017) Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep 7:5611|
|Halabi, Carmen M; Broekelmann, Thomas J; Lin, Michelle et al. (2017) Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv 3:e1602532|
|Valderrama, Carolina; Clark, Amy; Urano, Fumihiko et al. (2017) Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol 47:830-840|
|Keppel, Molly P; Cooper, Megan A (2016) Assessment of NK Cell Metabolism. Methods Mol Biol 1441:27-42|
|Clark, Amy L; Urano, Fumihiko (2016) Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol 43:60-66|
|Lee, Vivian S; Halabi, Carmen M; Hoffman, Erin P et al. (2016) Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A 113:8759-64|
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