Vascular disease defined as disorders of the arteries, veins, lymphatics and microcirculation is the most common cause of morbidity and mortalitiy in our society. By virtue of its scope and complexity, the care of patients with vascular disease has been fragmentary and often incomplete. In contrast, Vascular Medicine proposes to provide comprehensive evaluation and coordinate comprehensive treatment for all vascular disease. Unfortunately, the number of Vascular Medicine specialists required to meet this healthcare imperative is currently inadequate. An infrastructure of academic Vascular Medicine specialists is required to meet this deficiency. In order to provide specialists in Vascular Medicine with research skills and clinical knowledge to assume academic leadership in the field the applicant proposes: 1. To create an effective and sustainable post-graduate program that will provide didactic clinical research training and provide comprehensive clinical training in vascular disease through development of: a. A multidisciplinary research core curriculum in vascular disease providing didactic training in research methodologies and statistical methods to design and conduct independent clinical vascular research;b. A multidisciplinary clinical core curriculum providing comprehensive evaluation, coordinated management, and longitudinal care of vascular disease. To ensure the successful synthesis of research and clinical training, the curriculum will be constructed within the famework of a mentoring team that will combine a faculty member from each core. The importance of this program is that it will serve as the training prototype for Vascular Medicine. Implementation and replication of this program will provide the future academic leaders in Vascular Medicine who will define the field as a distinct discipline.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HL083772-03
Application #
7628435
Study Section
Special Emphasis Panel (ZHL1-CSR-A (F1))
Program Officer
Scott, Jane
Project Start
2007-07-01
Project End
2013-06-30
Budget Start
2009-07-01
Budget End
2011-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$995,130
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Rogers, Wade T; Zhang, Lifeng; Welden, Scott et al. (2017) Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes. Cytometry B Clin Cytom 92:258-265
Englund, Erin K; Rodgers, Zachary B; Langham, Michael C et al. (2016) Measurement of skeletal muscle perfusion dynamics with pseudo-continuous arterial spin labeling (pCASL): Assessment of relative labeling efficiency at rest and during hyperemia, and comparison to pulsed arterial spin labeling (PASL). J Magn Reson Imaging 44:929-39
Aparicio, Hugo J; Carr, Brendan G; Kasner, Scott E et al. (2015) Racial Disparities in Intravenous Recombinant Tissue Plasminogen Activator Use Persist at Primary Stroke Centers. J Am Heart Assoc 4:e001877
Ouma, Geoffrey O; Rodriguez, Eduardo; Muthumani, Karuppiah et al. (2014) In vivo electroporation of constitutively expressed HIF-1? plasmid DNA improves neovascularization in a mouse model of limb ischemia. J Vasc Surg 59:786-93
Eraso, Luis H; Fukaya, Eri; Mohler 3rd, Emile R et al. (2014) Peripheral arterial disease, prevalence and cumulative risk factor profile analysis. Eur J Prev Cardiol 21:704-11
Mesquita, Rickson C; Putt, Mary; Chandra, Malavika et al. (2013) Diffuse optical characterization of an exercising patient group with peripheral artery disease. J Biomed Opt 18:57007
Mullen, Michael T; Kasner, Scott E; Kallan, Michael J et al. (2013) Joint commission primary stroke centers utilize more rt-PA in the nationwide inpatient sample. J Am Heart Assoc 2:e000071
Degoma, Emil M; Davis, Mat D; Dunbar, Richard L et al. (2013) Discordance between non-HDL-cholesterol and LDL-particle measurements: results from the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 229:517-23
Ouma, Geoffrey O; Zafrir, Barak; Mohler 3rd, Emile R et al. (2013) Therapeutic angiogenesis in critical limb ischemia. Angiology 64:466-80
Mullen, Michael T; Judd, Suzanne; Howard, Virginia J et al. (2013) Disparities in evaluation at certified primary stroke centers: reasons for geographic and racial differences in stroke. Stroke 44:1930-5

Showing the most recent 10 out of 43 publications