This K12 Competitive Renewal Application describes our Program at the University of Pennsylvania (PENN) and the Children's Hospital of Philadelphia (CHOP) for training the next generation of outstanding clinical and translational non-malignant ("classic") hematology investigators, including adult and pediatric transfusion investigators. During the first iteration of this K12, our Program was very successful with all fiv of our K12 scholars rising to become Assistant Professors in Hematology Divisions at academic medical centers around the county. The academic environment and resources at PENN and CHOP provide a fertile training ground, and our Institution is committed to continue to contribute both materially and intellectually to the success of this Training Program. We also recently opened the Institute for Translational Medicine and Therapeutics (ITMAT), and the Blood Center at PENN &CHOP. These new entities expand the already rich environment for training our scholars, and provide an ideal setting for this Career Development Program, which will be structured to cover: Hemostasis, Red Cell Disorders, Immune Hematology and Transfusion Medicine, Stem Cells, Bone Marrow Failure and Myeloproliferative Disorders to meet the intent of this K12 Competitive.
There is currently a national shortage of physicians who are skilled at investigating non- malignant blood diseases. This is an application to continue a training program that will guide scholars as they acquire the necessary skills to design and execute clinical trials aimed at improving the care of patients with these blood disorders. This training program involves rigorous classroom work, intensive mentoring, and hands-on experience.
|Sullivan, Spencer K; Mills, Jason A; Koukouritaki, Sevasti B et al. (2014) High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood 123:753-7|
|Williams, David A; Bennett, Carolyn; Bertuch, Alison et al. (2014) Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer 61:869-74|
|Oshrine, Benjamin R; Olson, Timothy S; Bunin, Nancy (2014) Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for non-malignant disease. Pediatr Blood Cancer 61:1852-9|
|Paluru, Prasuna; Hudock, Kristin M; Cheng, Xin et al. (2014) The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells. Stem Cell Res 12:441-51|
|Olson, Timothy S; Chan, Elaine S; Paessler, Michele E et al. (2014) Liver failure due to hepatic angiosarcoma in an adolescent with dyskeratosis congenita. J Pediatr Hematol Oncol 36:312-5|
|Babushok, Daria V; Xie, Hongbo M; Roth, Jacquelyn J et al. (2014) Single nucleotide polymorphism array analysis of bone marrow failure patients reveals characteristic patterns of genetic changes. Br J Haematol 164:73-82|
|Carty, Shannon A; Koretzky, Gary A; Jordan, Martha S (2014) Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PLoS One 9:e106659|
|Sood, S L; Cuker, A; Wang, C et al. (2013) Similarity in joint function limitation in Type 3 von Willebrand's disease and moderate haemophilia A. Haemophilia 19:595-601|
|Caselli, Anna; Olson, Timothy S; Otsuru, Satoru et al. (2013) IGF-1-mediated osteoblastic niche expansion enhances long-term hematopoietic stem cell engraftment after murine bone marrow transplantation. Stem Cells 31:2193-204|
|Cuker, Adam (2012) Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost 38:31-7|
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