The Clinical Hematology Research Career Development Program at Washington University prepares trainees (Heme Scholars) to address complex problems in non-malignant blood diseases and transfusion medicine and alleviate the shortage of academic physician-scientists in these medically important disciplines. Scholars are clinical or research Fellows, clinical or research Instructors, or recently appointed Assistant Professors. One or two Scholars per year are selected for the program, which provides support for two or three years of career development. Scholars pursue a Clinical Curriculum that involves inpatient and outpatient care of patients with specific non-malignant hematologic disorders, and a Didactic Curriculum that teaches the skills necessary for independent and ethical clinical research. The Didactic Curriculum draws on the strengths of postdoctoral and degree granting programs in biostatistics, epidemiology, public health, and clinical research at Washington University. Each Scholar participates in an intensive Mentored Research Experience to generate publishable results and preliminary data for subsequent independent grant applications. The program focuses on three major areas: (1) hematopoietic stem cell and leukocyte disorders, including paroxysmal nocturnal hemoglobinuria, aplastic anemia, congenital anemias, myleodysplastic syndrome and myeloproliferative disorders, and cellular therapies using hematopoietic stem cells;(2) hemostatic and thrombotic disorders, including von Willebrand disease, thrombotic microangiopathy, and other congenital or acquired hemorrhagic or thrombotic syndromes;and (3) hemoglobinopathies and transfusion medicine, including sickle cell disease and clinical issues involving transfusion support or apheresis. These research projects encompass pediatric, adolescent and adult subjects with non-malignant hematologic disorders. The program is designed to recruit outstanding Scholars from diverse backgrounds, to individualize their training based on their needs and experience, to continuously monitor and improve the curriculum, and to track Scholar performance. By these means, the Heme Scholar program expects to increase our national capacity for multidisciplinary translational and clinical research in non-malignant hematology and transfusion medicine.

Public Health Relevance

Non-malignant blood diseases of many kinds remain major threats to public health. The Clinical Hematology Research Career Development Program at Washington University trains the next generation of physician- scientists to improve the diagnosis and treatment of non-malignant blood diseases and to improve transfusion therapy for adults and children affected by these diseases. !

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHL1-CSR-J (F1))
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Mondoro, Traci
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Fisher, D A C; Malkova, O; Engle, E K et al. (2017) Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia. Leukemia 31:1962-1974
Guilliams, Kristin P; Fields, Melanie E; Ragan, Dustin K et al. (2017) Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy. Pediatr Neurol 69:49-57
Guilliams, Kristin P; Fields, Melanie E; Ragan, Dustin K et al. (2017) Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia. Blood :
Xiao, Daphne Y; Luo, Suhong; O'Brian, Katiuscia et al. (2017) Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy. Leuk Lymphoma 58:851-858
Fields, Melanie E; Hoyt-Drazen, Catherine; Abel, Regina et al. (2016) A pilot study of parent education intervention improves early childhood development among toddlers with sickle cell disease. Pediatr Blood Cancer 63:2131-2138
Sanfilippo, Kristen Marie; Keller, Jesse; Gage, Brian F et al. (2016) Statins Are Associated With Reduced Mortality in Multiple Myeloma. J Clin Oncol 34:4008-4014
Wong, Terrence N; Miller, Christopher A; Klco, Jeffery M et al. (2016) Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML. Blood 127:893-7
Duncavage, E J; O'Brien, J; Vij, K et al. (2016) Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome. Leukemia 30:2422-2426
Sanfilippo, K M; Wang, T F; Gage, B F et al. (2016) Incidence of venous thromboembolism in patients with non-Hodgkin lymphoma. Thromb Res 143:86-90
Xiao, Daphne Y; Luo, Suhong; O'Brian, Katiuscia et al. (2016) Impact of sarcopenia on treatment tolerance in United States veterans with diffuse large B-cell lymphoma treated with CHOP-based chemotherapy. Am J Hematol 91:1002-7

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