We propose a K12 training program in genetics/genomics of lung disease for the Washington DC area. The proposed K12 will be integrated into the recently created Washington Institute of Clinical Translational Science, a consortium of Washington DC area academic medical centers. The Program will draw upon NIH-funded lung and sleep researchers from four institutions: Children's National Medical Center, Howard University (a historically black university), Georgetown University, and George Washington University. The administration of the Program and laboratory training in genetics/genomics will be centered in the Research Center for Genetic Medicine in Children's National Medical Center. The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the proposed K12 genetics/genomics of lung training program. Formal Core Courses in genetics, genomics and proteomics will be taught at CNMC, GWU, and GU. The Didactic Research Curriculum will utilize the educational programs that have been developed to support K awards at CNMC and the other three participating institutions. Potential trainees will be drawn from all four participating institutions and aligned with mentors and projects that best match their interests and career trajectory. Research strengths of the proposed K12 lead and secondary mentors focus on asthma, lung remodeling, acute lung injury, sleep disorders, pediatric lung health, and health disparities in lung disease, as well as on genetics, genomics and proteomics. Technical strengths in genetics/genomics that will be used in research projects include single nucleotide polymorphism (SNP) association studies, mRNA and proteomic profiling, and bioinformatics. We propose to train three Basic and/or Clinical Translational Fellows per year, for a total of 6-8 trainees graduating from the rigorous program over the proposed 5 yr period.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HL090020-05
Application #
8121646
Study Section
Special Emphasis Panel (ZHL1-CSR-A (S1))
Program Officer
Colombini-Hatch, Sandra
Project Start
2007-09-27
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$399,600
Indirect Cost
$29,600
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Restrepo-Gualteros, S M; Rodriguez-Martinez, C E; Jaramillo-Barberi, L E et al. (2015) Adolescent form of sporadic lymphangioleiomyomatosis (S-LAM). Allergol Immunopathol (Madr) 43:111-4
Rodríguez-Martínez, Carlos E; Melo-Rojas, Andrea; Restrepo-Gualteros, Sonia M et al. (2014) Validation of the Spanish version of the childhood asthma control test (cACT) in a population of Hispanic children. J Asthma 51:855-62
Rodríguez-Martínez, Carlos E; Nino, Gustavo; Castro-Rodriguez, Jose A (2014) Validation of the Spanish version of the Test for Respiratory and Asthma Control in Kids (TRACK) in a population of Hispanic preschoolers. J Allergy Clin Immunol Pract 2:326-31.e3
Huseni, Shehlanoor; Gutierrez, Maria J; Rodriguez-Martinez, Carlos E et al. (2014) The link between rhinitis and rapid-eye-movement sleep breathing disturbances in children with obstructive sleep apnea. Am J Rhinol Allergy 28:e56-61
Pillai, Dinesh K; Sankoorikal, Binu-John V; Johnson, Eric et al. (2014) Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium. Am J Respir Cell Mol Biol 50:292-300
Payne, P W (2014) Ancestry-based pharmacogenomics, adverse reactions and carbamazepine: is the FDA warning correct? Pharmacogenomics J 14:473-80
Restrepo-Gualteros, Sonia M; Jaramillo-Barberi, Lina E; Gonzalez-Santos, Monica et al. (2014) Characterization of cytomegalovirus lung infection in non-HIV infected children. Viruses 6:2038-51
Perez, Geovanny F; Pancham, Krishna; Huseni, Shehlanoor et al. (2014) Rhinovirus infection in young children is associated with elevated airway TSLP levels. Eur Respir J 44:1075-8
Brown, Kristy J; Seol, Haeri; Pillai, Dinesh K et al. (2013) The human secretome atlas initiative: implications in health and disease conditions. Biochim Biophys Acta 1834:2454-61
Duarte-Dorado, Diana M; Madero-Orostegui, Danitza S; Rodriguez-Martinez, Carlos E et al. (2013) Validation of a scale to assess the severity of bronchiolitis in a population of hospitalized infants. J Asthma 50:1056-61

Showing the most recent 10 out of 15 publications