We propose a K12 training program in genetics/genomics of lung disease for the Washington DC area. The proposed K12 will be integrated into the recently created Washington Institute of Clinical Translational Science, a consortium of Washington DC area academic medical centers. The Program will draw upon NIH-funded lung and sleep researchers from four institutions: Children's National Medical Center, Howard University (a historically black university), Georgetown University, and George Washington University. The administration of the Program and laboratory training in genetics/genomics will be centered in the Research Center for Genetic Medicine in Children's National Medical Center. The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the proposed K12 genetics/genomics of lung training program. Formal Core Courses in genetics, genomics and proteomics will be taught at CNMC, GWU, and GU. The Didactic Research Curriculum will utilize the educational programs that have been developed to support K awards at CNMC and the other three participating institutions. Potential trainees will be drawn from all four participating institutions and aligned with mentors and projects that best match their interests and career trajectory. Research strengths of the proposed K12 lead and secondary mentors focus on asthma, lung remodeling, acute lung injury, sleep disorders, pediatric lung health, and health disparities in lung disease, as well as on genetics, genomics and proteomics. Technical strengths in genetics/genomics that will be used in research projects include single nucleotide polymorphism (SNP) association studies, mRNA and proteomic profiling, and bioinformatics. We propose to train three Basic and/or Clinical Translational Fellows per year, for a total of 6-8 trainees graduating from the rigorous program over the proposed 5 yr period.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Physician Scientist Award (Program) (PSA) (K12)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-A (S1))
Program Officer
Colombini-Hatch, Sandra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Research Institute
United States
Zip Code
Pancham, Krishna; Sami, Iman; Perez, Geovanny F et al. (2016) Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity. Pediatr Neonatol 57:27-34
Aragona, Elena; El-Magbri, Eussra; Wang, Justin et al. (2016) Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus. Hosp Pediatr 6:211-8
Nino, Gustavo; Govindan, R B; Al-Shargabi, Tareq et al. (2016) Premature Infants Rehospitalized because of an Apparent Life-Threatening Event Had Distinctive Autonomic Developmental Trajectories. Am J Respir Crit Care Med 194:379-81
Pancham, Krishna; Perez, Geovanny F; Huseni, Shehlanoor et al. (2015) Premature infants have impaired airway antiviral IFNγ responses to human metapneumovirus compared to respiratory syncytial virus. Pediatr Res 78:389-94
Perez, Geovanny F; Pancham, Krishna; Huseni, Shehlanoor et al. (2015) Rhinovirus-induced airway cytokines and respiratory morbidity in severely premature children. Pediatr Allergy Immunol 26:145-52
Okada, Kazunori; Golbaz, Marzieh; Mansoor, Awais et al. (2015) Severity quantification of pediatric viral respiratory illnesses in chest X-ray images. Conf Proc IEEE Eng Med Biol Soc 2015:165-8
Rodriguez-Martinez, Carlos E; Rodriguez, Diego Andres; Nino, Gustavo (2015) Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country. J Med Virol 87:774-81
Wu, Xiaofang; Mimms, Remy; Banigan, Maureen et al. (2015) Development of glandular models from human nasal progenitor cells. Am J Respir Cell Mol Biol 52:535-42
Restrepo-Gualteros, S M; Rodriguez-Martinez, C E; Jaramillo-Barberi, L E et al. (2015) Adolescent form of sporadic lymphangioleiomyomatosis (S-LAM). Allergol Immunopathol (Madr) 43:111-4
Perez, Geovanny F; Rodriguez-Martinez, Carlos E; Nino, Gustavo (2015) Rhinovirus-Induced Airway Disease: A Model to Understand the Antiviral and Th2 Epithelial Immune Dysregulation in Childhood Asthma. J Investig Med 63:792-5

Showing the most recent 10 out of 32 publications