In recognition of the growing importance of genetics and genomics techniques applied to human disease, and in awareness of the extent to which lung disease research could benefit from expanded use of these technologies, we propose the Colorado Pulmonary Genetics and Genomics Program (CPGGP) for the career development of scholars in pulmonary genetics and genomics research. Objectives of the proposed career development program: Train leaders in the field of clinical research in lung disease genetics and genomics Build a curriculum combining the best of our existing pulmonary medicine training, human medical genetics, and clinical sciences programs Increase collaboration Recruit excellent scholars from various backgrounds Our proposed program responds to the NHLBI blueprint and has the following components for achieving these objectives: A curriculum designed to bring all scholars to a commensurate understanding of the fundamentals and realities of lung disease genetics and genomics research, regardless of their background Breadth of study through research opportunities in ongoing genetics and/or genomics research in one of four major lung diseases: Acute Lung Injury / Acute Respiratory Distress Syndrome (ALI/ARDS), Pulmonary Hypertension (PH), Chronic Obstructive Pulmonary Disease / Cancer Prevention (COPD/CA), and Granulomatous Lung Disease Collaboration through co-mentored research projects Preparation for independent clinical research through training in clinical research design, regulatory oversight, grant writing, human subject use, and ethics inherent in human medical genetics research Program evaluation and trainee follow-up The Program assimilates the expertise resident in Pulmonary Diseases, Medical Genetics, Bioinformatics, and the Clinical Sciences Training Program in order to afford Scholars the opportunity for significant choices regarding their journey through the Program, and optimizing their future success. In the current paradigm, not only will Scholars benefit, but Mentors will also profit through their involvement in the Program. By more broadly covering selected Pulmonary Diseases, the Program can have a pronounced impact on the application of genetics and genomics to lung diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHL1-CSR-A (S1))
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Colombini-Hatch, Sandra
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University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
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Baker, Christopher D; Alvira, Cristina M (2014) Disrupted lung development and bronchopulmonary dysplasia: opportunities for lung repair and regeneration. Curr Opin Pediatr 26:306-14
Poole, Alex; Urbanek, Cydney; Eng, Celeste et al. (2014) Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol 133:670-8.e12
Walter, Nicholas D; Painter, John; Parker, Matthew et al. (2014) Persistent latent tuberculosis reactivation risk in United States immigrants. Am J Respir Crit Care Med 189:88-95
Cattamanchi, Adithya; Walter, Nicholas D; Metcalfe, John Z et al. (2013) A transcriptional signature for active TB: have we found the needle in the haystack? PLoS Med 10:e1001539
Baker, Christopher D; Seedorf, Gregory J; Wisniewski, Benjamin L et al. (2013) Endothelial colony-forming cell conditioned media promote angiogenesis in vitro and prevent pulmonary hypertension in experimental bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 305:L73-81
Walter, Nicholas D; Strong, Michael; Belknap, Robert et al. (2012) Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis. Respirology 17:772-91
Burnham, Ellen L; Moss, Marc; Geraci, Mark W (2010) The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med 181:1159-60
Geraci, Mark W; Bull, Todd M; Tuder, Rubin M (2010) Genomics of pulmonary arterial hypertension: implications for therapy. Heart Fail Clin 6:101-14
Fujinaga, Hideshi; Baker, Christopher D; Ryan, Sharon L et al. (2009) Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. Am J Physiol Lung Cell Mol Physiol 297:L1160-9